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DDC antibody

DDC Reactivity: Rat, Cow WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN318954
  • Target See all DDC Antibodies
    DDC (Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC))
    Reactivity
    • 70
    • 42
    • 33
    • 9
    • 8
    • 6
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Rat, Cow
    Host
    • 60
    • 9
    • 2
    • 2
    Rabbit
    Clonality
    • 58
    • 15
    Polyclonal
    Conjugate
    • 37
    • 6
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This DDC antibody is un-conjugated
    Application
    • 58
    • 29
    • 26
    • 16
    • 13
    • 13
    • 13
    • 10
    • 8
    • 4
    • 3
    • 1
    Western Blotting (WB)
    Specificity
    This antibody recognises DOPA decarboxylase (aromatic-L-amino acid decarboxylase, DDC).
    Purification
    Affinity Chromatography.
    Immunogen
    SDS denatured, recombinant bovine DOPA decarboxylase expressed E. coli and purified from inclusion bodies.
    Isotype
    IgG
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    Discover our top product DDC Primary Antibody
  • Application Notes
    Western Blot: 1/1000. This antibody detects a band of approximately 55 kDa in rat adrenalmedulla.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    10 mM HEPES pH 7.5, 150 mM NaCl containing 0.09 % Sodium Azide as preservative and 0.01 % BSA, 50 % Glycerol as stabilizer.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    DDC (Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC))
    Alternative Name
    AADC / DDC (DDC Products)
    Synonyms
    AADC antibody, wu:fa56d05 antibody, wu:fd59h03 antibody, wu:fk20h01 antibody, zgc:65801 antibody, zgc:76929 antibody, Ddc antibody, DdcDv antibody, Dvir\\GJ17995 antibody, GJ17995 antibody, dvir_GLEANR_2561 antibody, Aadc antibody, 5-HT antibody, CG10697 antibody, DDC antibody, DdcDm antibody, Dmel\\CG10697 antibody, ddc antibody, fDDC antibody, l(2)37Bl antibody, l(2)37Ch antibody, l(2)k02104 antibody, dopa decarboxylase antibody, Dopa-decarboxylase antibody, dopa decarboxylase (aromatic L-amino acid decarboxylase) antibody, Dopa decarboxylase antibody, dopa decarboxylase L homeolog antibody, DDC antibody, ddc antibody, Ddc antibody, Dvir\Ddc antibody, ddc.L antibody
    Background
    DOPA decarboxylase is an enzyme implicated in 2 metabolic pathways, synthesizing 2 important neurotransmitters: dopamine and serotonin which both play key roles in many clinical disorders, including Parkinson's disease. Following the hydroxylation of tyrosine to form L dihydroxyphenylalanine (LDOPA), catalyzed by tyrosine hydroxylase, DDC decarboxylates LDOPA to form dopamine. This neurotransmitter is found in different areas of the brain and is particularly abundant in basal ganglia. Dopamine is also produced by DDC in the sympathetic nervous system and is the precursor of the catecholaminergic hormones, noradrenaline and adrenaline in the adrenal medulla. In the nervous system, tryptophan hydroxylase produces 5 OH tryptophan, which is decarboxylated by DDC, giving rise to serotonin. DDC is a homodimeric, pyridoxal phosphate dependent enzyme.Synonyms: Aromatic-L-amino-acid decarboxylase, DOPA decarboxylase
    Gene ID
    280762
    NCBI Accession
    NP_776332
    UniProt
    P27718
    Pathways
    Dopaminergic Neurogenesis
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