Apoptotic Peptidase Activating Factor 1 (APAF1) (AA 12-28) antibody

Details for Product No. ABIN319002
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Antigen
Synonyms
APAF1, ARK, Apaf-1, Apaf1, CG6829, D-Apaf-1, DARK, Dapaf-1, Dapaf-1/HAC-1, Dark, Dark/Apaf-I, Dark/Dapaf-1/HAC1, Dark/Hac-1/dApaf-1, Dark/Hac-1/dApaf1, Dmel\\CG6829, Hac-1, Hac-1/Dark, Hac1, T1, anon- ... show more
APAF1, ARK, Apaf-1, Apaf1, CG6829, D-Apaf-1, DARK, Dapaf-1, Dapaf-1/HAC-1, Dark, Dark/Apaf-I, Dark/Dapaf-1/HAC1, Dark/Hac-1/dApaf-1, Dark/Hac-1/dApaf1, Dmel\\CG6829, Hac-1, Hac-1/Dark, Hac1, T1, anon-53Fa, apaf-1, apaf1, arc, ark, dAPAF-1, dApaf-1, dApaf-1/DARK/HAC-1, dApaf1, dArk, dapaf, dapaf-1, dapaf-1L, dapaf-1S, dark, dark/dapaf-1/hac-1, dark/hac-1/dapaf-1, hac-1, hac1, l(2)SH0173, APAF-1, CED4, 6230400I06Rik, Apaf1l, fog, mKIAA0413, zgc:136543 show less
Epitope
AA 12-28
(48), (38), (10), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(167), (91), (83), (24), (15), (12), (1), (1), (1), (1), (1)
Host
Rabbit
(134), (38), (6), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application
Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(126), (59), (49), (42), (20), (20), (11), (11), (8), (7), (6), (3), (1), (1)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN319002
357.50 $
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Immunogen Synthetic peptide corresponding to amino acids 12-28 of Human Apaf1
Isotype IgG
Specificity This antibody recognises a 130 kDa band in Western blots.
Purification Afinity Chromatography
Alternative Name APAF1
Background Apaf1 (Apoptosis protease activating factor 1) is the mammalian homologue of the CED-4 cell death protein in C. Elegans. Apaf1 binds to cytochrome C and caspase-9 leading to caspase-9 activation, resulting in the beginning of the proteolytic cascade characteristic of apoptosis. Apaf1 can also associate with caspase-4 and caspase-8.Synonyms: Apaf-1, Apoptotic protease-activating factor 1, KIAA0413
Gene ID 317
NCBI Accession NP_001151
UniProt O14727
Research Area Cancer, Apoptosis/Necrosis
Application Notes Western Blot: 1/1000 - 1/2000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer PBS, 0.02 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
anti-Apoptotic Peptidase Activating Factor 1 (APAF1) (AA 12-28) antibody anti-Apoptotic Peptidase Activating Factor 1 (APAF1) (AA 12-28) antibody
anti-Apoptotic Peptidase Activating Factor 1 (APAF1) (AA 12-28) antibody (2) anti-Apoptotic Peptidase Activating Factor 1 (APAF1) (AA 12-28) antibody (Image 2)
Background publications Zou, Henzel, Liu et al.: "Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3." in: Cell, Vol. 90, Issue 3, pp. 405-13, 1997 (PubMed).

Cecconi, Alvarez-Bolado, Meyer et al.: "Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development." in: Cell, Vol. 94, Issue 6, pp. 727-37, 1998 (PubMed).

Validation Images
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