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Details for Product No. ABIN319002

Apoptotic Peptidase Activating Factor 1 (APAF1) (AA 12-28) antibody

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Antigen
Synonyms
APAF-1, CED4, 6230400I06Rik, Apaf-1, Apaf1l, fog, mKIAA0413, apaf-1, zgc:136543, APAF1, ARK, Apaf1, CG6829, D-Apaf-1, DARK, Dapaf-1, Dapaf-1/HAC-1, Dark, Dark/Apaf-I, Dark/Dapaf-1/HAC1, Dark/Hac-1/dAp ... show more
Epitope
»Alternatives AA 12-28
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN319002
Quantity 0.1 mg
Price
346.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Synthetic peptide corresponding to amino acids 12-28 of Human Apaf1
Isotype IgG
Specificity This antibody recognises a 130kD band in Western blots.
Purification Afinity Chromatography
Alternative Name APAF1
Background Apaf1 (Apoptosis protease activating factor 1) is the mammalian homologue of the CED-4 cell death protein in C. Elegans. Apaf1 binds to cytochrome C and caspase-9 leading to caspase-9 activation, resulting in the beginning of the proteolytic cascade characteristic of apoptosis. Apaf1 can also associate with caspase-4 and caspase-8.
Alternate names: Apaf-1, Apoptotic protease-activating factor 1, KIAA0413
Gene ID 317
NCBI Accession NP_001151.1
UniProt O14727
Research Area Cancer, Apoptosis/Necrosis
Application Notes Western Blot: 1/1000 - 1/2000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS, 0.02% Sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Zou, Henzel, Liu et al.: "Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3." in: Cell, Vol. 90, Issue 3, pp. 405-13, 1997 (PubMed).

Cecconi, Alvarez-Bolado, Meyer et al.: "Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development." in: Cell, Vol. 94, Issue 6, pp. 727-37, 1998 (PubMed).

Alternatives for antigen "Apoptotic Peptidase Activating Factor 1 (APAF1)", type "Antibodies"
Hosts (133), (29), (6), (3)
Reactivities (162), (89), (80), (24), (15), (12), (1), (1), (1), (1), (1), (1)
Applications (122), (48), (46), (44), (24), (20), (11), (9), (8), (4), (2), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Epitopes (49), (35), (11), (2), (2), (2), (2), (1), (1), (1), (1), (1)
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