Apoptotic Peptidase Activating Factor 1 (APAF1) (AA 12-28) antibody

Details for Product No. ABIN319003
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Antigen
Synonyms
APAF-1, CED4, 6230400I06Rik, Apaf-1, Apaf1l, fog, mKIAA0413, apaf-1, zgc:136543, APAF1, ARK, Apaf1, CG6829, D-Apaf-1, DARK, Dapaf-1, Dapaf-1/HAC-1, Dark, Dark/Apaf-I, Dark/Dapaf-1/HAC1, Dark/Hac-1/dAp ... show more
APAF-1, CED4, 6230400I06Rik, Apaf-1, Apaf1l, fog, mKIAA0413, apaf-1, zgc:136543, APAF1, ARK, Apaf1, CG6829, D-Apaf-1, DARK, Dapaf-1, Dapaf-1/HAC-1, Dark, Dark/Apaf-I, Dark/Dapaf-1/HAC1, Dark/Hac-1/dApaf-1, Dark/Hac-1/dApaf1, Dmel\\CG6829, Hac-1, Hac-1/Dark, Hac1, T1, anon-53Fa, apaf1, arc, ark, dAPAF-1, dApaf-1, dApaf-1/DARK/HAC-1, dApaf1, dArk, dapaf, dapaf-1, dapaf-1L, dapaf-1S, dark, dark/dapaf-1/hac-1, dark/hac-1/dapaf-1, hac-1, hac1, l(2)SH0173 show less
Epitope
AA 12-28
(46), (35), (8), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(160), (90), (82), (24), (15), (12), (1), (1), (1), (1), (1)
Host
Rabbit
(132), (38), (6), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(124), (58), (52), (45), (20), (20), (14), (11), (7), (4), (3), (1), (1)
Pubmed 2 references available
Catalog no. ABIN319003
Quantity 50 µg
Price
286.00 $   Plus shipping costs $45.00
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Synthetic peptide corresponding to amino acids 12-28 of Human Apaf1
Isotype IgG
Specificity This antibody recognises a 130kD band in Western blots.
Purification Afinity Chromatography
Alternative Name APAF1
Background Apaf1 (Apoptosis protease activating factor 1) is the mammalian homologue of the CED-4 cell death protein in C. Elegans. Apaf1 binds to cytochrome C and caspase-9 leading to caspase-9 activation, resulting in the beginning of the proteolytic cascade characteristic of apoptosis. Apaf1 can also associate with caspase-4 and caspase-8.
Alternate names: Apaf-1, Apoptotic protease-activating factor 1, KIAA0413
Gene ID 317
NCBI Accession NP_001151.1
UniProt O14727
Research Area Cancer, Apoptosis/Necrosis
Application Notes Western Blot: 1/1000 - 1/2000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS, 0.02% Sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Apoptotic Peptidase Activating Factor 1 (APAF1) (AA 12-28) antibody anti-Apoptotic Peptidase Activating Factor 1 (APAF1) (AA 12-28) antibody
anti-Apoptotic Peptidase Activating Factor 1 (APAF1) (AA 12-28) antibody (2) anti-Apoptotic Peptidase Activating Factor 1 (APAF1) (AA 12-28) antibody (Image 2)
Background publications Zou, Henzel, Liu et al.: "Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3." in: Cell, Vol. 90, Issue 3, pp. 405-13, 1997 (PubMed).

Cecconi, Alvarez-Bolado, Meyer et al.: "Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development." in: Cell, Vol. 94, Issue 6, pp. 727-37, 1998 (PubMed).

Hosts (132), (38), (6), (2)
Reactivities (160), (90), (82), (24), (15), (12), (1), (1), (1), (1), (1)
Applications (124), (58), (52), (45), (20), (20), (14), (11), (7), (4), (3), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Epitopes (46), (35), (8), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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