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Details for Product No. ABIN319340

Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA) (Tyr136) antibody

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Antigen
Synonyms NACP, PARK1, PARK4, PD1
Epitope
»Alternatives Tyr136
Reactivity
»Alternatives Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN319340
Quantity 50 µg
Price
242.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen The antiserum was produced against synthesized non-phosphopeptide derived from human alpha-Synuclein around the phosphorylation site of Tyrosine 136 (Q-D-Yp-E-P).
Specificity Antibody detects endogenous levels of total alpha-Synuclein protein.
Purification Immunoaffinity Chromatography
Alternative Name Alpha-Synuclein / SNCA
Background Alpha Synuclein is implicated in the regulation of dopamine release and transport. It is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). In the nervous system, alpha Synuclein is primarily located at presynaptic terminals and is found membrane bound in dopaminergic neurons. It can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies), including Parkinson's Disease. Alpha Synuclein induces fibrillization of microtubule associated protein tau and reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase 3 activation. Alpha synuclein is a protein phosphorylated predominantly on serine residues.
Alternate names: NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, PARK1
Gene ID 6622
NCBI Accession NP_000336.1
UniProt P37840
Research Area Neurology
Application Notes Western Blot: 1/500~1/1000. Immunofluorescence: 1/100~1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% Sodium Azide and 50% Glycerol.
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at-20°C.
Expiry Date 12 months
Background publications Goldberg, Lansbury: "Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease?" in: Nature cell biology, Vol. 2, Issue 7, pp. E115-9, 2000 (PubMed).

Negro, Brunati, Donella-Deana et al.: "Multiple phosphorylation of alpha-synuclein by protein tyrosine kinase Syk prevents eosin-induced aggregation." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 16, Issue 2, pp. 210-2, 2002 (PubMed).

Takahashi, Yamashita, Nagano et al.: "Identification and characterization of a novel Pyk2/related adhesion focal tyrosine kinase-associated protein that inhibits alpha-synuclein phosphorylation." in: The Journal of biological chemistry, Vol. 278, Issue 43, pp. 42225-33, 2003 (PubMed).

Chen, Chang, Liao et al.: "Humidity effect on the decay of second-order nonlinearity in thermally poled fused silica." in: Optics express, Vol. 14, Issue 25, pp. 12334-40, 2009 (PubMed).

Alternatives for antigen "Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA)", type "Antibodies"
Hosts (251), (93), (16), (13), (1)
Reactivities (357), (170), (147), (91), (87), (78), (24), (24), (2), (1), (1), (1)
Applications (236), (135), (93), (80), (59), (49), (22), (16), (13), (8), (6), (3), (2), (1), (1), (1)
Conjugates (11), (9), (9), (8), (8), (8), (8), (8), (8), (8), (8)
Epitopes (36), (31), (25), (23), (20), (12), (9), (8), (8), (6), (6), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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