Reticulon 4 (RTN4) (AA 460-510) antibody

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Antigen
Synonyms
RTN4-Cw, DKFZp459C0314, NOGO, NOGO-A, reticulon-4, ASY, NI220/250, NOGOC, NSP, NSP-CL, Nbla00271, Nbla10545, Nogo-B, Nogo-C, RTN-X, RTN4-A, RTN4-B1, RTN4-B2, RTN4-C, 1110020G17Rik, AA407876, AA409940, ... show more
RTN4-Cw, DKFZp459C0314, NOGO, NOGO-A, reticulon-4, ASY, NI220/250, NOGOC, NSP, NSP-CL, Nbla00271, Nbla10545, Nogo-B, Nogo-C, RTN-X, RTN4-A, RTN4-B1, RTN4-B2, RTN4-C, 1110020G17Rik, AA407876, AA409940, AA960376, C130026I10Rik, NgA, Nogo-A, mKIAA0886, mKIAA4153, NI-250, Nogo, Vp20, r, rat N, rat NogoA, NGR, NOGOR, NgR, NgR1, Nogor show less
Epitope
AA 460-510
(18), (17), (17), (12), (12), (6), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus), Mouse (Murine)
(112), (82), (81), (3), (3), (2), (1), (1), (1)
Host
Rabbit
(118), (8), (5), (3), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(108), (58), (45), (32), (20), (6), (6), (4), (4), (1)
Pubmed 5 references available
Quantity 500 μg
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Immunogen A synthetic peptide from aa region 460-510 of human NOGO conjugated to an immunogenic carrier protein was used as the antigen.
Isotype IgG
Specificity Specific for Nogo.
Alternative Name NOGO (RTN4 Antibody Abstract)
Background Function: Potent neurite growth inhibitor in vitro and plays a role both in the restriction of axonal regeneration after injury and in structural plasticity in the CNS.
Subcellular location: Endoplasmic reticulum membrane, Multi-pass membrane protein. Note: Anchored to the membrane of the endoplasmic reticulum through 2 putativetransmembrane domains.
Tissue specificity: Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 is testis-specific. Also known as: RTN4, Neurite outgrowth inhibitor, Reticulon-4, Nogo protein, Foocen, Neuroendocrine-specific protein, NSP, Neuroendocrine-specific protein C homolog, RTN-x, Reticulon-5.
Application Notes A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Sjöblom, Jones, Wood et al.: "The consensus coding sequences of human breast and colorectal cancers. ..." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).

Zhou, Sha, Li et al.: "Expression of a novel reticulon-like gene in human testis." in: Reproduction (Cambridge, England), Vol. 123, Issue 2, pp. 227-34, 2002 (PubMed).

Tagami, Eguchi, Kinoshita et al.: "A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity." in: Oncogene, Vol. 19, Issue 50, pp. 5736-46, 2000 (PubMed).

Yang, Yu, Bi et al.: "Assignment of the human reticulon 4 gene (RTN4) to chromosome 2p14-->2p13 by radiation hybrid mapping." in: Cytogenetics and cell genetics, Vol. 88, Issue 1-2, pp. 101-2, 2000 (PubMed).

Prinjha, Moore, Vinson et al.: "Inhibitor of neurite outgrowth in humans." in: Nature, Vol. 403, Issue 6768, pp. 383-4, 2000 (PubMed).

Validation Images
Catalog No. ABIN350522
454.67 $
Plus shipping costs $45.00
Quantity
Price
500 μg
454.67 $

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