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Details for Product No. ABIN350917

Synaptotagmin II (SYT2) (N-Term) antibody

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Synonyms SytII, R74640, mKIAA4194, SYNII, RATSYNII, si:ch211-236j4.1
»Alternatives N-Term
»Alternatives Human, Mouse (Murine), Rat (Rattus)
»Alternatives Sheep
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN350917
Quantity 500 µg
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the n-terminal region of human Synaptotagmin-2 (Synaptotagmin II, SytII, SYT2) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat and mouse.
Isotype IgG
Specificity Appears to be specific for SYTII.
Purity IgG
Alternative Name Synaptotagmin 2 (Synaptotagmin II, SytII, SYT2, Synaptotagmin-2)
Background Synaptotagmins, like SYT2, are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.
Function: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domains.
Subunit: Homotetramer. Interacts with stonin 2.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Cytoplasmic vesicle, secretory vesicle, chromaffin granule. Note: Synaptic vesicles and chromaffin granules. Also known as: Synaptotagmin II, SytII, SYT2.
UniProt Q8N9I0
Application Notes IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Geppert, Archer, Südhof: "Synaptotagmin II. A novel differentially distributed form of synaptotagmin." in: The Journal of biological chemistry, Vol. 266, Issue 21, pp. 13548-52, 1991 (PubMed).

Fukuda, Aruga, Niinobe et al.: "Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II." in: The Journal of biological chemistry, Vol. 269, Issue 46, pp. 29206-11, 1994 (PubMed).

Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).

Alternatives for antigen "Synaptotagmin II (SYT2)", type "Antibodies"
Hosts (37), (5), (3), (3)
Reactivities (43), (28), (27), (13), (12), (12), (12), (1), (1), (1), (1)
Applications (28), (11), (10), (10), (5), (5), (5), (4), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (11), (5), (4), (2), (2), (2), (2), (1), (1), (1), (1)