Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) (Extracellular Domain) antibody

Details for Product No. ABIN351075
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Antigen
Synonyms GP145-TrkB, TRKB, trk-B, Tkrb, trkB, AI848316, C030027L06Rik, RATTRKB1, TRKB1, Trk-B, TrkB, trkb, trkb-b, xtrkb, si:ch211-220b11.1, trkB2, NTRK2, ntrk2, gp145-trkb
Epitope
Extracellular Domain
(34), (34), (16), (16), (8), (7), (5), (5), (5), (4), (4), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus)
(196), (150), (150), (27), (25), (24), (12), (1)
Host
Sheep
(194), (14), (5), (4), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(141), (77), (74), (40), (29), (27), (9), (4), (4), (3), (2), (1)
Pubmed 6 references available
Catalog no. ABIN351075
Quantity 500 µg
Price
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide from the extracellular domain of mouse TrkB (BDNF/NT-3 growth factors receptor, TrkB tyrosine kinase, Trk-B) conjugated to an immunogenic carrier protein was used as the antigen.
Isotype IgG
Specificity Specific for RAB5A.
Purification IgG
Alternative Name TrkB (BDNF/NT-3 growth factors receptor,TrkB tyrosine kinase, Trk-B)
Background Function: Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.
Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subunit: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and ARMS.
Subcellular location: Membrane, Single-pass type I membrane protein. Also known as: Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, GP145-TrkB/GP95-TrkB, Trk-B, BDNF/NT-3 growth factors receptor.
UniProt O88565
Research Area Signaling
Application Notes A concentration of 10-50 µg/mL is recommended.
The optimal concentration should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
Expiry Date 12 months
General Soppet, Escandon, Maragos et al.: "The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor." in: Cell, Vol. 65, Issue 5, pp. 895-903, 1991 (PubMed).

Klein, Conway, Parada et al.: "The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain." in: Cell, Vol. 61, Issue 4, pp. 647-56, 1990 (PubMed).

Klein, Parada, Coulier et al.: "trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development." in: The EMBO journal, Vol. 8, Issue 12, pp. 3701-9, 1990 (PubMed).

Ninkina, Grashchuck, Buchman et al.: "TrkB variants with deletions in the leucine-rich motifs of the extracellular domain." in: The Journal of biological chemistry, Vol. 272, Issue 20, pp. 13019-25, 1997 (PubMed).

Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome...." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).

Ballif, Carey, Sunyaev et al.: "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain." in: Journal of proteome research, Vol. 7, Issue 1, pp. 311-8, 2008 (PubMed).

Hosts (194), (14), (5), (4), (2)
Reactivities (196), (150), (150), (27), (25), (24), (12), (1)
Applications (141), (77), (74), (40), (29), (27), (9), (4), (4), (3), (2), (1)
Conjugates (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Epitopes (34), (34), (16), (16), (8), (7), (5), (5), (5), (4), (4), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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