Search, Find and Buy Antibodies, ELISA Kits and Proteins.
Loading Loading
Order hotline:
phone +1 404 474 4654
fax +1 888 205 9894 (TF)
Details for Product No. ABIN351077

Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) (Extracellular Domain) antibody

Request
Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms GP145-TrkB, TRKB, trk-B, Tkrb, trkB, AI848316, C030027L06Rik, RATTRKB1, TRKB1, Trk-B, TrkB, trkb, trkb-b, xtrkb, si:ch211-220b11.1, trkB2, NTRK2, ntrk2, gp145-trkb
Epitope
»Alternatives Extracellular Domain
Reactivity
»Alternatives Mouse (Murine), Rat (Rattus), Human
Host
»Alternatives Sheep
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 7 references available
Catalog no. ABIN351077
Quantity 500 µg
Price
454.67 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the extracellular domain of rat, mouse TrkB (BDNF/NT-3 growth factors receptor, TrkB tyrosine kinase, Trk-B) conjugated to an immunogenic carrier protein was used as the immunogen.
Isotype IgG
Specificity Specific for CHMP3.
Purity IgG
Alternative Name TrkB (BDNF/NT-3 growth factors receptor,TrkB tyrosine kinase, Trk-B)
Background Function: Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.
Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subunit: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and ARMS.
Subcellular location: Membrane, Single-pass type I membrane protein. Also known as: Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, GP145-TrkB/GP95-TrkB, Trk-B, BDNF/NT-3 growth factors receptor.
UniProt Q9CQ10
Application Notes A concentration of 10-50 µg/mL is recommended.
The optimal concentration should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
Expiry Date 12 months
Haniu, Talvenheimo, Le et al.: "Extracellular domain of neurotrophin receptor trkB: disulfide structure, N-glycosylation sites, and ligand binding." in: Archives of biochemistry and biophysics, Vol. 322, Issue 1, pp. 256-64, 1995 (PubMed).

Nakagawara, Liu, Ikegaki et al.: "Cloning and chromosomal localization of the human TRK-B tyrosine kinase receptor gene (NTRK2)." in: Genomics, Vol. 25, Issue 2, pp. 538-46, 1995 (PubMed).

Shelton, Sutherland, Gripp et al.: "Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 15, Issue 1 Pt 2, pp. 477-91, 1995 (PubMed).

Allen, Dawbarn, Eckford et al.: "Cloning of a non-catalytic form of human trkB and distribution of messenger RNA for trkB in human brain." in: Neuroscience, Vol. 60, Issue 3, pp. 825-34, 1994 (PubMed).

Ultsch, Wiesmann, Simmons et al.: "Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC." in: Journal of molecular biology, Vol. 290, Issue 1, pp. 149-59, 1999 (PubMed).

Stoilov, Castren, Stamm: "Analysis of the human TrkB gene genomic organization reveals novel TrkB isoforms, unusual gene length, and splicing mechanism." in: Biochemical and biophysical research communications, Vol. 290, Issue 3, pp. 1054-65, 2002 (PubMed).

Greenman, Stephens, Smith et al.: "Patterns of somatic mutation in human cancer genomes." in: Nature, Vol. 446, Issue 7132, pp. 153-8, 2007 (PubMed).

Alternatives for antigen "Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2)", type "Antibodies"
Hosts (180), (13), (5), (4), (4)
Reactivities (180), (147), (147), (27), (25), (24), (12), (1)
Applications (134), (67), (62), (40), (39), (26), (8), (8), (5), (4), (2), (2), (1)
Conjugates (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Epitopes (29), (29), (16), (13), (6), (6), (5), (5), (4), (4), (4), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Beacon