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TRKB antibody (Neurotrophic Tyrosine Kinase, Receptor, Type 2) (Extracellular Domain)

Details for Product anti-NTRK2 Antibody No. ABIN351079, Supplier: Log in to see
Antigen
  • trkb
  • trkb-b
  • xtrkb
  • si:ch211-220b11.1
  • trkB2
  • NTRK2
  • ntrk2
  • gp145-trkb
  • TRKB
  • GP145-TrkB
  • trk-B
  • AI848316
  • C030027L06Rik
  • Tkrb
  • trkB
  • RATTRKB1
  • TRKB1
  • Trk-B
  • TrkB
Alternatives
anti-Mouse (Murine) TRKB antibody for Immunofluorescence
Epitope
Extracellular Domain, AA 400-450
27
23
20
15
15
14
13
13
12
11
7
7
6
6
6
5
5
5
5
4
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Rat (Rattus), Mouse (Murine)
232
145
140
9
6
4
4
4
2
Host
Rabbit
226
21
12
5
3
Clonality
Polyclonal
Conjugate
This TRKB antibody is un-conjugated
5
5
5
4
3
3
3
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (IHC), Western Blotting (WB)
186
102
89
37
26
24
7
6
4
2
2
2
1
1
Supplier
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Immunogen A synthetic peptide from aa region 400-450 of the extracellular domain of mouse TrkB conjugated to an immunogenic carrier protein was used as the antigen.
Isotype IgG
Specificity Specific for TrkB.
Alternative Name TrkB (NTRK2 Antibody Abstract)
Background Function: Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.
Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subunit: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and ARMS.
Subcellular location: Membrane, Single-pass type I membrane protein. Also known as: Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, GP145-TrkB/GP95-TrkB, Trk-B, BDNF/NT-3 growth factors receptor.
Research Area Cancer
Pathways RTK Signaling, Neurotrophin Signaling Pathway
Application Notes A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Ballif, Carey, Sunyaev et al.: "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain." in: Journal of proteome research, Vol. 7, Issue 1, pp. 311-8, 2008 (PubMed).

Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome. ..." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).

Ninkina, Grashchuck, Buchman et al.: "TrkB variants with deletions in the leucine-rich motifs of the extracellular domain." in: The Journal of biological chemistry, Vol. 272, Issue 20, pp. 13019-25, 1997 (PubMed).

Klein, Parada, Coulier et al.: "trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development." in: The EMBO journal, Vol. 8, Issue 12, pp. 3701-9, 1990 (PubMed).

Klein, Conway, Parada et al.: "The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain." in: Cell, Vol. 61, Issue 4, pp. 647-56, 1990 (PubMed).

Soppet, Escandon, Maragos et al.: "The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor." in: Cell, Vol. 65, Issue 5, pp. 895-903, 1991 (PubMed).