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Details for Product No. ABIN351218

Transient Receptor Potential Cation Channel, Subfamily M, Member 7 (TRPM7) (4th Cytoplasmic Loop) antibody

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Antigen
Synonyms ALSPDC, CHAK, CHAK1, LTRPC7, TRP-PLIK, Ltpr7, Ltrpc7, LTrpC-7, TRPPLIK, 2310022G15Rik, 4833414K03Rik, 5033407O22Rik, Chak, Trp-plik, cb495, TRPM7, chak, chak1, ltrpc7, trp-plik
Epitope
»Alternatives 4th Cytoplasmic Loop
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 6 references available
Catalog no. ABIN351218
Quantity 500 µg
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the 4th cytoplasmic loop of human TRPM7 (LTRPC7) conjugated to an immunogenic carrier protein was used as the immunogen.
Isotype IgG
Specificity Appears to be specific for TRPM7.
Purity IgG
Alternative Name TRPM7 (LTRPC7)
Background TRPCs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.
Function: Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
Catalytic activity: ATP + a protein: ADP + a phosphoprotein.
Cofactor: Binds 1 zinc ion per subunit.
Subunit: Homodimer. Forms heterodimers with TRPM6.
Subcellular location: Membrane, Multi-pass membrane protein. Also known as: Transient receptor potential cation channel subfamily M member 7, long transient receptor potential channel 7, LTrpC7, channel-kinase 1, CHAK1, LTRPC7, CHAK, FLJ20117, FLJ25718, TRP-PLIK.
UniProt Q96QT4
Application Notes IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Schmitz, Perraud, Johnson et al.: "Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7." in: Cell, Vol. 114, Issue 2, pp. 191-200, 2003 (PubMed).

Ryazanova, Dorovkov, Ansari et al.: "Characterization of the protein kinase activity of TRPM7/ChaK1, a protein kinase fused to the transient receptor potential ion channel." in: The Journal of biological chemistry, Vol. 279, Issue 5, pp. 3708-16, 2004 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Chubanov, Waldegger, Mederos y Schnitzler et al.: "Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 9, pp. 2894-9, 2004 (PubMed).

Dorovkov, Ryazanov: "Phosphorylation of annexin I by TRPM7 channel-kinase." in: The Journal of biological chemistry, Vol. 279, Issue 49, pp. 50643-6, 2004 (PubMed).

Hermosura, Nayakanti, Dorovkov et al.: "A TRPM7 variant shows altered sensitivity to magnesium that may contribute to the pathogenesis of two Guamanian neurodegenerative disorders." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 32, pp. 11510-5, 2005 (PubMed).

Alternatives for antigen "Transient Receptor Potential Cation Channel, Subfamily M, Member 7 (TRPM7)", type "Antibodies"
Hosts (50), (11), (8), (4)
Reactivities (53), (37), (33), (20), (19), (17), (17), (2), (1), (1)
Applications (49), (23), (21), (21), (15), (12), (10), (6), (3), (2), (2), (2)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (17), (7), (5), (4), (2), (2), (2), (1), (1), (1)
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