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Details for Product No. ABIN356300

Pan Cytokeratin antibody

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»Alternatives Cow (Bovine), Chicken, Human, Monkey, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus)
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 2 references available
Catalog no. ABIN356300
Quantity 1 mL
368.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Human epidermal keratin. Remarks: Molecular weight of antigen: CK1 (67), CK2 (65. 5), CK3 (64), CK4 (59), CK5 (58)CK6 (56) CK8 (52. 5). + CK1 (67), CK2 (65. 5), CK3 (64), CK4 (59), CK5 (58) CK6 (56) CK8 (52. 5).
Clone AE1-AE3
Isotype IgG1
Characteristics Synonyms: pan Keratin, Cytokeratin Pan-reactive
Purification Protein A Chromatography.
Background Cytokeratins are intermediate filament keratins found in the intracytoplasmic cytoskeletonof epithelial tissue There are two types of Cytokeratins: the low weight, acidic type Icytokeratins and the high weight, basic or neutral type II. Cytokeratins are usually found inpairs comprising a type I Cytokeratin and a type II cytokeratin. The high molecular weightcytokeratins, which are the basic or neutral cytokeratins, comprise subtypes CK1(67),CK2(65. 5), CK3(64), CK4(59), CK5(58), CK6(56), CK7(54), CK8(52. 5) and CK9. The lowmolecular weight cytokeratins, which are the acidic cytokeratins, comprise subtypes CK10(56. 5), CK12 (56), CK13 (53), CK14 (50), CK16 (48), CK17 (46), CK18 (45), CK19 (48) and CK20(46).
Application Notes Suitable for Immunohistochemistry and Immunocytochemistry (Frozen or Formalin-FixedParaffin-Embedded (FFPE) tissue sections and cell smears). For IHC dilute concentrated antibody at 1/50-1/100, use streptavidin~biotin system orpolymer system, incubate 30 minutes at room temperature. For FFPE tissue sections antigen retriever like trypsin is required. Recommended Positive Control: Human skin, lung ca. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer PBS, pH 7.4 containing 1% BSA as stabilizer and 0.05% Sodium Azide as preservative.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: One year from despatch.
Expiry Date 12 months
Background publications Sun, Tseng, Huang et al.: "Monoclonal antibody studies of mammalian epithelial keratins: a review." in: Annals of the New York Academy of Sciences, Vol. 455, pp. 307-29, 1986 (PubMed).

Tseng, Jarvinen, Nelson et al.: "Correlation of specific keratins with different types of epithelial differentiation: monoclonal antibody studies." in: Cell, Vol. 30, Issue 2, pp. 361-72, 1983 (PubMed).

Alternatives for antigen "Pan Cytokeratin", type "Antibodies"
Hosts (22), (3), (2)
Reactivities (23), (12), (7), (7), (6), (5), (4), (2), (2), (1), (1), (1), (1)
Applications (25), (17), (10), (10), (7), (4), (1), (1)
Conjugates (1), (1), (1)
Epitopes (1), (1), (1), (1), (1)