Synaptophysin antibody (C-Term)

Catalog No. ABIN356461

Product Details anti-Synaptophysin Antibody

Target: Synaptophysin (SYP)

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Synaptophysin antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificity: This antibody reacts with Synaptophysin in neuroendocrine neoplasm of neural as well as epithelial type. Cellular localization: Cytoplasmic.

Purification: Protein A Chromatography.

Immunogen: A synthetic peptide from C-terminus of Human Synaptophysin.

Isotype: IgG

Application Details

Application Notes: Immunohistochemistry for Formalin-Fixed Paraffin Embedded (FFPE) Tissue Sections andFrozen Sections: Dilute 1/100-1/200 using polymer or streptavidin approx. Biotin system for 30 mins at RT. This antibody requires antigen retriever (boiling FFPE tissue sections in 10 mMcitrate buffer, pH 6.0 for 10-20 mins. followed by cooling at RT for 20 mins). Positive Control: Human pancreas or GI tumor.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 3.0 mg/mL

Buffer: 10 mM PO4, 150 mM NaCl, pH 7.4 containing 1 % BSA as stabilizer and 0.05 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for Synaptophysin

Target: Synaptophysin (SYP)

Alternative Name: Synaptophysin / SYP (SYP Products)

Synonyms: syp-B antibody, xsypii antibody, MGC86267 antibody, MRXSYP antibody, A230093K24Rik antibody, AI848995 antibody, Syn antibody, p38 antibody, Syp1 antibody, mrxsyp antibody, syp antibody, xsypi antibody, synaptophysin S homeolog antibody, synaptophysin antibody, synaptophysin L homeolog antibody, synaptophysin a antibody, syp.S antibody, SYP antibody, syp antibody, Syp antibody, syp.L antibody, sypa antibody

Background: Synaptophysin is a synaptic vesicle glycoprotein with 4 transmembrane domain MW 38 kDa. Thisproteinis present in the membrane of neuronal presynaptic vesicles in brain, spinal cord, retina, vesicles of adrenal medulla, neuromuscular junctions, and endocrine cells. It is also expressed by neuroendocrine cells throughout the body, both normal and neoplastic. Synaptophysin is also marker of endocrine tumors. It is a useful marker for the identification of normal neuroendocrine cells and neuroendocrine neoplasms.Synonyms: Major synaptic vesicle protein p38, Neuroendocrine Marker

Gene ID: 6855

NCBI Accession: NP_003170

UniProt: P08247

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of long-term Neuronal Synaptic Plasticity