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SETD8 antibody (C-Term)
SETD8
Reactivity: Human
WB, EIA
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-SETD8 Antibody
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Target
See all SETD8 Antibodies
SETD8
(SET Domain Containing (Lysine Methyltransferase) 8 (SETD8))
Binding Specificity
All epitopes for SETD8 antibodies
AA 364-393, C-Term
Reactivity
All reactivities for SETD8 antibodies
Human
Host
All hosts for SETD8 antibodies
Rabbit
Clonality
All clonalities for SETD8 antibodies
Polyclonal
Conjugate
All conjugates for SETD8 antibodies
This SETD8 antibody is un-conjugated
Application
All applications for SETD8 antibodies
Western Blotting (WB), Enzyme Immunoassay (EIA)
Specificity
This antibody is specific to Human SETD8 / SET07 (C-term)
Purification
Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Immunogen
KLH conjugated synthetic peptide between 364~393 amino acids from the C-terminal region of human SET07
Isotype
Ig Fraction
Top Product
Discover our top product SETD8 Primary Antibody
Alternatives
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Application Details
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Application Notes
ELISA: 1/1,000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
0.25 mg/mL
Buffer
PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Target Details for SETD8
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Target
SETD8
(SET Domain Containing (Lysine Methyltransferase) 8 (SETD8))
Alternative Name
SETD8 / SET07 (SETD8 Products )
Synonyms
KMT5A antibody, PR-Set7 antibody, SET07 antibody, SET8 antibody, 2410195B05Rik antibody, AA617402 antibody, AW536475 antibody, PR-SET7 antibody, setd8b antibody, wu:fc23f12 antibody, zgc:171649 antibody, Pr-set7 antibody, RGD1305893 antibody, Setd8 antibody, kmt5a antibody, kmt5a-a antibody, setd8 antibody, setd8-a antibody, set8a antibody, setd8a antibody, wu:fj33f02 antibody, zgc:153719 antibody, lysine methyltransferase 5A antibody, lysine methyltransferase 5Ab antibody, lysine methyltransferase 5A S homeolog antibody, lysine methyltransferase 5Aa antibody, KMT5A antibody, Kmt5a antibody, kmt5ab antibody, kmt5a.S antibody, kmt5aa antibody
Background
SET07 is a histone methyltransferase that methylates Lys-20 of histone H4. H4 Lys-20 methylation represents a specific tag for epigenetic transcriptional repression. The nuclear SET07 protein, which associates with silent chromatin on euchromatic arms but shows no association with constitutive heterochromatin, prefers nucleosomes as substrate compared to free histones. It appears that SET07 may play a role in maintaining silent chromatin by preventing neighboring acetylation of H4 tail. Although the SET domain contains the active site of enzymatic activity, both sequences upstream and downstream of the SET domain are required for methyltransferase activity.Synonyms: H4-K20-HMTase SETD8, Histone-lysine N-methyltransferase SETD8, KMT5A, Lysine N-methyltransferase 5A, PR-Set7, PR/SET domain-containing protein 07, PRSET7, SET domain-containing protein 8, SET8
Gene ID
387893, 9606
UniProt
Q9NQR1
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