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SMT3 Suppressor of Mif Two 3 Homolog 1/2/3 (S. Cerevisiae) (SUMO1/2/3) antibody

Details for Product No. ABIN356808
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Antigen
Reactivity
Human
(1)
Host
Rabbit
(1)
Clonality
Polyclonal
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(1), (1), (1)
Pubmed 7 references available
Quantity 0.4 mL
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Catalog No. ABIN356808
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Immunogen This antibody is generated from rabbits immunized with a recombinant protein encoding full length of human SUMO1.
Specificity This antibody recoganize all 3 SUMO isoforms, including human SUMO1, SUMO2 and SUMO3.
Purification Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name SUMO1/2/3
Background Covalent modification of target lysines by SUMO (small ubiquitin-like modifier) modulates processes such as protein localization, transcription, nuclear transport, mitosis, DNA replication and repair, signal transduction, and viral reproduction. SUMO does not seem to be involved in protein degradation and may in fact function as an antagonist of ubiquitin in the degradation process. The SUMO family consists of SUMO1 and closely related homologs SUMO2, SUMO3, and SUMO4. Sumoylation has been shown to regulate a wide range of proteins, including MDM2, PIAS, PML, RanGAP1, RanBP2, p53, p73, HIPK2, TEL, c- Jun, Fas, Daxx, TNFRI, Topo-I, Topo-II, PARK2, WRN, Sp100, IkB-alpha, Androgen receptor (AR), GLUT1/4, CaMK, DNMT3B, TDG, HIF1A, CHD3, EXOSC9, RAD51, and viral targets such as CMV-IE1/2, EBV-BZLF1, and HPV/BPV-E1.
Alternate names: GMP1, HSMT3, PIC1, SMT3 homolog 1, SMT3B, SMT3C, SMT3H1, SMT3H2, SMT3H3, SUMO-1, SUMO-2, SUMO-3, Sentrin, Sentrin-2, Small ubiquitin-like modifier, UBL1
Gene ID 7341
NCBI Accession NP_001005781
UniProt P63165
Application Notes ELISA: 1/1,000. Western blot: 1/100-1/500. Immunohistochemistry on paraffin sections: 1/50-1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Supplier Images
anti-SMT3 Suppressor of Mif Two 3 Homolog 1/2/3 (S. Cerevisiae) (SUMO1/2/3) antibody anti-SMT3 Suppressor of Mif Two 3 Homolog 1/2/3 (S. Cerevisiae) (SUMO1/2/3) antibody
anti-SMT3 Suppressor of Mif Two 3 Homolog 1/2/3 (S. Cerevisiae) (SUMO1/2/3) antibody (2) anti-SMT3 Suppressor of Mif Two 3 Homolog 1/2/3 (S. Cerevisiae) (SUMO1/2/3) antibody (Image 2)
Background publications Oh, Claussen, Kim: "Motor and sensory demyelinating mononeuropathy multiplex (multifocal motor and sensory demyelinating neuropathy): a separate entity or a variant of chronic inflammatory demyelinating polyneuropathy?" in: Journal of the peripheral nervous system : JPNS, Vol. 2, Issue 4, pp. 362-9, 2000 (PubMed).

Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Ohshima, Shimotohno: "Transforming growth factor-beta-mediated signaling via the p38 MAP kinase pathway activates Smad-dependent transcription through SUMO-1 modification of Smad4." in: The Journal of biological chemistry, Vol. 278, Issue 51, pp. 50833-42, 2003 (PubMed).

Bailey, OHare: "Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1." in: The Journal of biological chemistry, Vol. 279, Issue 1, pp. 692-703, 2003 (PubMed).

Pountney, Huang, Burns et al.: "SUMO-1 marks the nuclear inclusions in familial neuronal intranuclear inclusion disease." in: Experimental neurology, Vol. 184, Issue 1, pp. 436-46, 2003 (PubMed).

Ling, Sankpal, Robertson et al.: "Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription." in: Nucleic acids research, Vol. 32, Issue 2, pp. 598-610, 2004 (PubMed).

Yang, Sharrocks: "SUMO promotes HDAC-mediated transcriptional repression." in: Molecular cell, Vol. 13, Issue 4, pp. 611-7, 2004 (PubMed).

Validation Images
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