OAS3 antibody (C-Term)

Catalog No. ABIN358718

Product Details anti-OAS3 Antibody

Target: OAS3 (2'-5' Oligoadenylate Synthetase 3 (OAS3))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OAS3 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to OAS3.

Purification: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human OAS3.

Isotype: Ig Fraction

Application Details

Application Notes: ELISA: 1/1,000. Western blotting: 1/100 - 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for OAS3

Target: OAS3 (2'-5' Oligoadenylate Synthetase 3 (OAS3))

Alternative Name: OAS3 (OAS3 Products)

Synonyms: p100 antibody, Oasl10 antibody, 2'-5'-oligoadenylate synthetase 3 antibody, 2'-5' oligoadenylate synthetase 3 antibody, OAS3 antibody, Oas3 antibody

Background: OAS3 is an interferon inducible protein that belongs to the 2-5A synthetase family, may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. OAS3 synthesizes preferentially dimeric 2',5'-oligoadenylate molecules. GTP can be an alternative substrate. OAS3 binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs. The protein is present at high level in placenta trophoblast.Synonyms: (2-5')oligo(A) synthetase 3, 2'-5'-oligoadenylate synthetase 3, 2-5A synthetase 3, p100 OAS

Gene ID: 4940, 9606

UniProt: Q9Y6K5

Pathways: Hepatitis C