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RPTOR Independent Companion of MTOR, Complex 2 (RICTOR) (N-Term) antibody

Details for Product No. ABIN359480, Supplier: Log in to see
Antigen
  • PIA
  • mAVO3
  • 4921505C17Rik
  • 6030405M08Rik
  • AVO3
  • AW492497
  • D530039E11Rik
  • Fyb
Alternatives
anti-Human RPTOR Independent Companion of MTOR, Complex 2 antibody for Western Blotting
Epitope
N-Term
26
24
13
13
5
5
4
3
3
3
3
3
3
2
2
2
2
2
2
1
1
Reactivity
Human
139
46
12
5
5
1
1
Host
Rabbit
90
32
19
Clonality
Polyclonal
Conjugate
Un-conjugated
4
4
4
3
3
3
2
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
92
72
59
25
21
12
12
7
6
5
2
1
1
1
Supplier
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human RICTOR.
Isotype Ig
Specificity This antibody detects RICTOR at N-term.
Purification Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name RICTOR (RICTOR Antibody Abstract)
Background RICTOR and MTOR (FRAP1) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth.Synonyms: KIAA1999, Rapamycin-insensitive companion of mTOR, mAVO3
Molecular Weight 192087 Da
Gene ID 253260, 9606
UniProt Q6R327
Research Area Signaling
Pathways Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes ELISA 1: 1,000. Western blot 1: 50 - 1: 100. Immunohistochemsitry 1: 10 - 1: 50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-RPTOR Independent Companion of MTOR, Complex 2 (RICTOR) (N-Term) antibody (ABIN359480) Formalin-fixed and paraffin-embedded human testis tissue reacted with RICTOR antibody...
Western Blotting (WB) image for anti-RPTOR Independent Companion of MTOR, Complex 2 (RICTOR) (N-Term) antibody (ABIN359480) Western blot analysis of anti-RICTOR Pab in SK-BR-3 cell line lysates (35 µg/lane). R...
Background publications Pearce, Huang, Boudeau et al.: "Identification of Protor as a novel Rictor-binding component of mTOR complex-2." in: The Biochemical journal, Vol. 405, Issue 3, pp. 513-22, 2007 (PubMed).

Yang, Inoki, Ikenoue et al.: "Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity." in: Genes & development, Vol. 20, Issue 20, pp. 2820-32, 2006 (PubMed).

Jacinto, Facchinetti, Liu et al.: "SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity." in: Cell, Vol. 127, Issue 1, pp. 125-37, 2006 (PubMed).