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CDK1 antibody (Cyclin-Dependent Kinase 1) (Thr14)

Details for Product anti-CDK1 Antibody No. ABIN359656, Supplier: Log in to see
Antigen
  • 5363
  • cdc
  • cdc-2
  • cdc2
  • Cdc2
  • CDC2
  • cdc2-a
  • Cdc2a
  • CDC2A
  • CDC2AAT
  • cdc2Dm
  • cdc2x1.1
  • cdc28a
  • CDC28A
  • CDCDm
  • Cdk-1
  • Cdk1
  • CDK1
  • cdk1
  • CDK1/CDC2
  • CDK2
  • CDKA1
  • CDKA;1
  • cell division control 2
  • CG5363
  • CYCLIN-DEPENDENT KINASE A;1
  • Dcdc2
  • dCdk1
  • Dmcdc2
  • Dm cdc2
  • DmCdc2
  • DmCdk1
  • Dmel\\CG5363
  • group 4
  • l(2)31Eh
  • p34
  • p34cdc2
  • P34CDC2
  • POL3
  • pold
  • PSTAIR
  • wu:fc30e01
  • xcdc2
  • zgc:92032
Alternatives
anti-Human CDK1 antibody for Immunocytochemistry
Epitope
Thr14
98
74
48
33
33
29
20
19
17
15
15
14
14
14
14
8
7
6
6
5
5
5
5
4
4
3
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
682
296
267
44
38
32
31
28
22
21
18
10
9
7
6
6
6
4
2
2
2
2
1
1
1
1
1
1
1
1
Host
Rabbit
510
230
Clonality
Polyclonal
Conjugate
This CDK1 antibody is un-conjugated
30
27
25
20
16
16
9
8
8
5
5
5
5
5
5
3
3
3
3
3
3
3
3
3
3
3
2
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
603
279
173
129
110
79
60
55
51
36
10
10
7
6
6
2
1
1
1
1
Supplier
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Immunogen KLH conjugated synthetic peptide corresponding to amino acid residues surrounding T14 of human CDK1.
Isotype Ig
Specificity This antibody reacts to CDK1.
Purification Affinity chromatography on Protein G
Alternative Name CDK1 (CDK1 Antibody Abstract)
Background CDK1 is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control.Synonyms: CDC2, CDC28A, CDK1, CDKN1, Cell division control protein 2 homolog, Cell division protein kinase 1, Cyclin-dependent kinase 1, P34CDC2, p34 protein kinase
Gene ID 983, 9606
UniProt P06493
Pathways Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes ELISA: 1/1,000. Western blotting: 1/50 - 1/100. Immunohistochemistry: 1/10 - 1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-CDK1 antibody (Cyclin-Dependent Kinase 1) (Thr14) (ABIN359656) Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with CDK1 ...
Western Blotting (WB) image for anti-CDK1 antibody (Cyclin-Dependent Kinase 1) (Thr14) (ABIN359656) Western blot analysis of CDK1(arrow) using rabbit polyclonal CDK1 Antibody. 293 cell ...
Background publications Krämer, Mailand, Lukas, Syljuåsen, Wilkinson, Nigg, Bartek, Lukas: "Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase." in: Nature cell biology, Vol. 6, Issue 9, pp. 884-91, 2004 (PubMed).

Dai, Yamasaki, Yang, Sayama, Shirakata, Tokumara, Yahata, Tohyama, Hashimoto: "Keratinocyte G2/M growth arrest by 1,25-dihydroxyvitamin D3 is caused by Cdc2 phosphorylation through Wee1 and Myt1 regulation." in: The Journal of investigative dermatology, Vol. 122, Issue 6, pp. 1356-64, 2004 (PubMed).

Litvak, Argov, Dahan, Ramachandran, Amarilio, Shainskaya, Lev: "Mitotic phosphorylation of the peripheral Golgi protein Nir2 by Cdk1 provides a docking mechanism for Plk1 and affects cytokinesis completion." in: Molecular cell, Vol. 14, Issue 3, pp. 319-30, 2004 (PubMed).