EPH Receptor A4 antibody (EPHA4) (C-Term)

Details for Product anti-EPHA4 Antibody No. ABIN359795, Supplier: Log in to see
Antigen
  • ephe
  • EPHA4
  • Ci-Eph1
  • sek
  • hek8
  • rtk1
  • tyr01
  • 2900005C20Rik
  • AI385584
  • Cek8
  • Hek8
  • Sek
  • Sek1
  • Tyro1
  • rb
  • HEK8
  • SEK
  • TYRO1
  • RGD1560587
  • EPH receptor A4
  • ephrin receptor epsilon
  • Eph receptor A4
  • EPHA4
  • ephe
  • epha4
  • Epha4
Alternatives
anti-Mouse (Murine) EPH Receptor A4 antibody for Western Blotting
Epitope
C-Term
29
21
20
15
13
12
11
10
7
5
4
4
4
3
2
2
1
1
1
1
1
1
1
1
Reactivity
Human
157
73
37
10
10
10
7
7
7
6
4
4
2
2
2
2
2
1
1
1
Host
Rabbit
150
23
17
2
Clonality
Polyclonal
Conjugate
This EPH Receptor A4 antibody is un-conjugated
9
8
8
6
6
6
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
133
85
85
50
19
17
13
7
4
1
1
1
Options
Supplier
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human EphA4.
Isotype Ig
Specificity This antibody reacts to EphA4.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name EPHA4 (EPHA4 Antibody Abstract)
Background Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).Synonyms: Ephrin type-A receptor 4, HEK8, Receptor protein-tyrosine kinase HEK8, SEK, TYRO1, Tyrosine-protein kinase TYRO1, Tyrosine-protein kinase receptor SEK
Gene ID 2043, 9606
UniProt P54764
Pathways RTK Signaling
Application Notes ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-EPH Receptor A4 (EPHA4) (C-Term) antibody (ABIN359795) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Western Blotting (WB) image for anti-EPH Receptor A4 (EPHA4) (C-Term) antibody (ABIN359795) (LEFT)Western blot analysis of anti-EphA4 Pab in NCI-H460 cell lysate. EphA4 (arrow) ...
Background publications Prevost, Woulfe, Tanaka, Brass: "Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 14, pp. 9219-24, 2002 (PubMed).

Xu, Mellitzer, Wilkinson: "Roles of Eph receptors and ephrins in segmental patterning." in: Philosophical transactions of the Royal Society of London. Series B, Biological sciences, Vol. 355, Issue 1399, pp. 993-1002, 2000 (PubMed).

Jordan, Solan, Dominguez, Sia, Hand, Lampe, Laird: "Trafficking, assembly, and function of a connexin43-green fluorescent protein chimera in live mammalian cells." in: Molecular biology of the cell, Vol. 10, Issue 6, pp. 2033-50, 1999 (PubMed).

Zhou: "The Eph family receptors and ligands." in: Pharmacology & therapeutics, Vol. 77, Issue 3, pp. 151-81, 1998 (PubMed).

Fox, Holst, Chute, Lindberg, Janssen, Basu, Welcher: "cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases." in: Oncogene, Vol. 10, Issue 5, pp. 897-905, 1995 (PubMed).

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