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Details for Product No. ABIN361679

Mitogen-Activated Protein Kinase 14 (MAPK14) antibody

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P38C-CRK, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA, CRK1, Csbp1, Csbp2, Exip, Hog, Prkm14, Prkm15, Sapk2A, p38Hog, p38alpha, Crk1, p38-alpha, p38MAPK, p38a, csb ... show more
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB), Immunoprecipitation (IP), ELISA
Pubmed 8 references available
Catalog no. ABIN361679
Quantity 25 µg
220.70 $   Plus shipping costs $45.00
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Availability Will be delivered in 3 to 4 Business Days
Immunogen Full length recombinant protein expressed in E.coli cells.
Clone 9F12
Isotype IgG1
Specificity Detects a approx. 38 kDa protein corresponding to the molecular mass of p38α MAPK on SDS PAGE immunoblots.
Cross-Reactivity (Details) No known cross-reactivity with other related human kinases,
Sensitivity Detects ~38kDa protein corresponding to p38alpha MAPK when loaded with 6ng of purified p38alpha by chemiluminescent immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Purification Protein G Purified
Alternative Name p38 alpha (MAP Kinase)
Background Synonyms:
CSAID Binding protein 1, CSBP1, CSBP2, EXIP, MAP kinase MXI2, MAPkinase p38alpha, MAPK14, p38 ALPHA, p38 MAP kinase, p38 mitogen activated protein kinase, RK, SAPK 2A, Stress activated protein kinase 2A
The MAPK (mitogen activated protein kinase) comprises a family of ubiquitous praline-directed, proteinserine/threonine kinases which signal transductionpathways that control intracellular events includingacute responses to hormones and major developmentalchanges in organisms. This super family consists ofstress activated protein kinases (SAPKs), extracellular signal-regulated kinases (ERKs), and p38 kinases, each of which forms a separate pathway. The kinase members that populate each pathway are sequentially activated by phosphorylation. Upon activation, p38 MAPK/SAPK2α translocates into the nucleus where it phosphorylates one or more nuclear substrates, effecting transcriptional changes and other cellular processes involved in cell growth, division, differentiation, inflammation, and death. Specifically p38 always acts as a pro-apoptotic factor with its activation leading to the release of cytochrome c from mitochondria and cleavage of caspase3 and its downstream effector, PARP. p38 MAPK is activated by a variety of chemical stress inducers including hydrogen peroxide, heavy metals, anisomycin, sodium salicylate, LPS, and biological stress signals such as tumor necrosis factor, interleukin-1, ionizing and UV irradiation, hyperosmotic stress and chemotherapeutic drugs. As a result, p38 alpha has been widely validated as a target for inflammatory disease including rheumatoidarthritis, COPD and psoriasis and has also been implicated in cancer, CNS and diabetes.
Gene ID 1432
NCBI Accession NP_001306.1
UniProt Q16539
Research Area Cell Signaling
Application Notes Recommended Dilution: 1:1000 (WB)
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer PBS, 50 % glycerol, 0.09 % sodium azide
Preservative Sodium azide
Storage -20 °C
Background publications Han, Lee, Bibbs et al.: "A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells." in: Science (New York, N.Y.), Vol. 265, Issue 5173, pp. 808-11, 1994 (PubMed).

Pearson, Robinson, Beers Gibson et al.: "Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions." in: Endocrine reviews, Vol. 22, Issue 2, pp. 153-83, 2001 (PubMed).

Deng, Ren, Yang et al.: "A JNK-dependent pathway is required for TNFalpha-induced apoptosis." in: Cell, Vol. 115, Issue 1, pp. 61-70, 2003 (PubMed).

Van Laethem, Van Kelst, Lippens et al.: "Activation of p38 MAPK is required for Bax translocation to mitochondria, cytochrome c release and apoptosis induced by UVB irradiation in human keratinocytes." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 18, Issue 15, pp. 1946-8, 2004 (PubMed).

Salojin, Owusu, Millerchip et al.: "Essential role of MAPK phosphatase-1 in the negative control of innate immune responses." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 3, pp. 1899-907, 2006 (PubMed).

Medicherla, Protter, Ma et al.: "Preventive and therapeutic potential of p38 alpha-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mice with type 1 diabetes." in: The Journal of pharmacology and experimental therapeutics, Vol. 318, Issue 1, pp. 99-107, 2006 (PubMed).

Fan, Chen, Qiao et al.: "Opposing effects of ERK and p38 MAP kinases on HeLa cell apoptosis induced by dipyrithione." in: Molecules and cells, Vol. 23, Issue 1, pp. 30-8, 2007 (PubMed).

Nemes, Petrovski, Aerts et al.: "Transglutaminase-mediated intramolecular cross-linking of membrane-bound alpha-synuclein promotes amyloid formation in Lewy bodies." in: The Journal of biological chemistry, Vol. 284, Issue 40, pp. 27252-64, 2009 (PubMed).

Alternatives for antigen "Mitogen-Activated Protein Kinase 14 (MAPK14)", type "Antibodies"
Hosts (266), (34), (2), (1)
Reactivities (292), (201), (195), (78), (49), (42), (16), (11), (7), (6), (6), (6), (6), (2), (1), (1), (1)
Applications (232), (102), (71), (53), (50), (44), (16), (12), (8), (8), (6), (3), (2), (2), (1), (1), (1), (1)
Conjugates (7), (6), (5), (5), (5), (5), (5), (5), (5), (5), (5)
Epitopes (80), (69), (16), (13), (12), (12), (9), (8), (6), (6), (6), (5), (4), (4), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)