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Catenin, beta (pSer45) antibody

Details for Product No. ABIN362089
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Antigen
Synonyms Catnb
Epitope
pSer45
(40), (40), (36), (33), (24), (20), (14), (14), (12), (12), (9), (7), (6), (4), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(292), (271), (266), (171), (156), (110), (4), (3), (2)
Host
Rabbit
(288), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(14), (14), (14), (14), (14), (14), (14), (14), (14), (14), (14), (1), (1)
Application
Western Blotting (WB)
(152), (140), (100), (55), (47), (11), (4), (1), (1)
Pubmed 5 references available
Quantity 50 µL
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days
Catalog No. ABIN362089
158.40 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Peptide sequence around phosphorylation site of pThr 41, pSer45 (A-T-T (p) -T-A-P-S (p) -L-S) derived from Human b-Catenin. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
Isotype IgG
Specificity The antibody detects endogenous level of b-Catenin only when phosphorylated at threonine 41/serine 45.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name beta-Catenin
Background Involved in the regulation of cell adhesion and in signal transduction through the Wnt pathway.
Molecular Weight 92 kDa
NCBI Accession NP_001091
UniProt P35222
Application Notes Western blotting: 1:500-1:1000
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Background publications Liu, Li, Semenov et al.: "Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism." in: Cell, Vol. 108, Issue 6, pp. 837-47, 2002 (PubMed).

Amit, Hatzubai, Birman et al.: "Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway." in: Genes & development, Vol. 16, Issue 9, pp. 1066-76, 2002 (PubMed).

Sakanaka: "Phosphorylation and regulation of beta-catenin by casein kinase I epsilon." in: Journal of biochemistry, Vol. 132, Issue 5, pp. 697-703, 2002 (PubMed).

Provost, Yamamoto, Lizardi et al.: "Functional correlates of mutations in beta-catenin exon 3 phosphorylation sites." in: The Journal of biological chemistry, Vol. 278, Issue 34, pp. 31781-9, 2003 (PubMed).

Provost, McCabe, Stern et al.: "Functional correlates of mutation of the Asp32 and Gly34 residues of beta-catenin." in: Oncogene, Vol. 24, Issue 16, pp. 2667-76, 2005 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN362089
158.40 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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