Stathmin 1 (STMN1) (pSer25) antibody

Details for Product No. ABIN362268
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Antigen
Synonyms
op18, stathmin, stmn1, stmn1a, lag, lap18, pp17, pp19, pr22, smn, fj43c10, wu:fj38b07, wu:fj43c10, zgc:110159, cb959, wu:fb14e04, zgc:136942, LOC100217988, C1orf215, LAP18, Lag, OP18, PP17, PP19, PR22 ... show more
op18, stathmin, stmn1, stmn1a, lag, lap18, pp17, pp19, pr22, smn, fj43c10, wu:fj38b07, wu:fj43c10, zgc:110159, cb959, wu:fb14e04, zgc:136942, LOC100217988, C1orf215, LAP18, Lag, OP18, PP17, PP19, PR22, SMN, 19k, Lap18, Op18, P18, P19, Pig, Pp17, Pp18, Pp19, Pr22, Smn, prosolin show less
Epitope
pSer25
(33), (24), (22), (22), (20), (19), (17), (17), (16), (15), (13), (5), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(314), (235), (217), (53), (34), (3), (1)
Host
Rabbit
(306), (6), (6)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (2), (2), (2), (2), (2)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(228), (141), (91), (90), (68), (42), (22), (19), (4), (2), (1)
Pubmed 4 references available
Quantity 100 µL
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Catalog No. ABIN362268
286.00 $
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Immunogen Peptide sequence around phosphorylation site of pSer25 (I-L-S (p) -P-R) derived from Human Stathmin 1. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
Isotype IgG
Specificity The antibody detects endogenous level of Stathmin 1 only when phosphorylated at serine 25.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name Stathmin 1
Background Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear
Molecular Weight 19 kDa
NCBI Accession NP_001138
UniProt P16949
Application Notes Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Background publications Zilfou, Hoffman, Sank et al.: "The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradation." in: Molecular and cellular biology, Vol. 21, Issue 12, pp. 3974-85, 2001 (PubMed).

Boehm, Yoshimoto, Crook et al.: "A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression." in: The EMBO journal, Vol. 21, Issue 13, pp. 3390-401, 2002 (PubMed).

Biernat, Wu, Timm et al.: "Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity." in: Molecular biology of the cell, Vol. 13, Issue 11, pp. 4013-28, 2002 (PubMed).

Vadlamudi, Barnes, Rayala et al.: "p21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor B." in: Molecular and cellular biology, Vol. 25, Issue 9, pp. 3726-36, 2005 (PubMed).

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