RPS6KB1 antibody (Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1) (AA 409-413)

Details for Product anti-RPS6KB1 Antibody No. ABIN362954, Supplier: Log in to see
Antigen
  • PS6K
  • S6K
  • S6K-beta-1
  • S6K1
  • STK14A
  • p70 S6KA
  • p70(S6K)-alpha
  • p70-S6K
  • p70-alpha
  • XPKAbeta
  • pkacb
  • 10539
  • 7084
  • CG10539
  • DS6K
  • Dmel\\CG10539
  • Dp70S6k
  • Dp70[s6k]
  • Dp70s6k
  • S6k
  • dS6K
  • dS6k
  • dp70[S6k]
  • dp70s6k
  • dps6k
  • ds6k
  • fs(3)07084
  • l(3)07084
  • p70 S6K
  • p70/S6K
  • p70S6K
  • p70[S6 kinase]
  • p70[S6K]
  • p70[S6k]
  • p70[S6kinase]
  • p70s6K
  • s6k
  • s6k11
  • 2610318I15Rik
  • 4732464A07Rik
  • 70kDa
  • AA959758
  • AI256796
  • AI314060
  • p70/85s6k
  • p70s6k
  • p70s6k-A
  • ribosomal protein S6 kinase, 70kDa, polypeptide 1
  • protein kinase, cAMP-dependent, catalytic, beta
  • RPS6-p70-protein kinase
  • ribosomal protein S6 kinase, polypeptide 1
  • p70 S6 kinase
  • RPS6KB1
  • prkacb
  • S6k
  • Rps6kb1
  • p70s6k-A
Alternatives
anti-Human RPS6KB1 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
AA 409-413
110
41
39
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3
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3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
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1
1
1
1
1
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1
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1
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Reactivity
Human, Mouse (Murine), Rat (Rattus)
709
445
422
73
54
41
34
33
21
13
13
8
5
5
3
3
1
Host
Rabbit
636
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2
Clonality
Polyclonal
Conjugate
This RPS6KB1 antibody is un-conjugated
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9
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1
1
1
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Application
Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
546
281
257
151
133
104
67
42
22
20
17
11
7
2
1
1
1
1
Options
Supplier
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Immunogen Peptide sequence around AA 409-413 (I-R-S-P-R) derived from Human p70 S6 Kinase. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Isotype IgG
Specificity The antibody detects endogenous level of total p70 S6 Kinase protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen. Specificity/Sensitivity p70 S6 Kinase (Ab-411) antibody detects endogenous levels of total p70 S6 Kinase protein.
Alternative Name p70 S6 Kinase (RPS6KB1 Antibody Abstract)
Background Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens. Promotes protein synthesis by phosphorylating PDCD4 at 'Ser-67' and targeting it for degradation.
Molecular Weight 85 kDa
NCBI Accession NP_003152
UniProt P23443
Research Area Signaling, Kinases/Phosphatases
Pathways PI3K-Akt Signaling, RTK Signaling, AMPK Signaling, Regulation of Cell Size, Skeletal Muscle Fiber Development, Feeding Behaviour, G-protein mediated Events, Smooth Muscle Cell Migration, Interaction of EGFR with phospholipase C-gamma
Application Notes Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100
Immunofluorescence: 1:100-1:200
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Background publications Le, Hittelman, Liu, McWatters, Li, Mills, Bast: "Paclitaxel induces inactivation of p70 S6 kinase and phosphorylation of Thr421 and Ser424 via multiple signaling pathways in mitosis." in: Oncogene, Vol. 22, Issue 4, pp. 484-97, 2003 (PubMed).

Krause, Bertrand, Hue: "Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes." in: European journal of biochemistry / FEBS, Vol. 269, Issue 15, pp. 3751-9, 2002 (PubMed).

Eguchi, Iwasaki, Ueno, Frank, Motley, Eguchi, Marumo, Hirata, Inagami et al.: "Intracellular signaling of angiotensin II-induced p70 S6 kinase phosphorylation at Ser(411) in vascular smooth muscle cells. Possible requirement of epidermal growth factor receptor, Ras, ..." in: The Journal of biological chemistry, Vol. 274, Issue 52, pp. 36843-51, 2000 (PubMed).

Papst, Sugiyama, Nagasawa, Lucas, Maller, Terada: "Cdc2-cyclin B phosphorylates p70 S6 kinase on Ser411 at mitosis." in: The Journal of biological chemistry, Vol. 273, Issue 24, pp. 15077-84, 1998 (PubMed).

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