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Protein Phosphatase 2, Catalytic Subunit, alpha Isozyme (PPP2CA) (N-Term) antibody

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Antigen
Alternatives
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Epitope
N-Term
(23), (17), (13), (11), (9), (9), (4), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(105), (70), (53), (11), (6), (6), (5), (2), (2), (1), (1)
Host
Rabbit
(102), (11), (4), (3), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(100), (42), (24), (23), (15), (12), (11), (6), (2), (2)
Pubmed 4 references available
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Quantity 50 μL
Shipping to United States ( )
Availability Will be delivered in 2 to 3 Business Days
Immunogen peptide Corresponding to the amino terminal sequence derived from human PP2A-a. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Isotype IgG
Specificity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.
Alternative Name PP2A-alpha (PPP2CA Antibody Abstract)
Background The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Molecular Weight 40 kDa
UniProt P67775
Pathways PI3K-Akt Signaling
Application Notes Western blotting: 1:500-1:1000
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Product cited in: Ma, Li, Wang et al.: "Atrial natriuretic peptide suppresses Th17 development through regulation of cGMP-dependent protein kinase and PI3K-Akt signaling pathways." in: Regulatory peptides, Vol. 181, pp. 9-16, 2013 (PubMed).

Background publications Janssens, Goris: "Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling." in: The Biochemical journal, Vol. 353, Issue Pt 3, pp. 417-39, 2001 (PubMed).

Yu, Du, Moreno et al.: "Methylation of the protein phosphatase 2A catalytic subunit is essential for association of Balpha regulatory subunit but not SG2NA, striatin, or polyomavirus middle tumor antigen." in: Molecular biology of the cell, Vol. 12, Issue 1, pp. 185-99, 2001 (PubMed).

Tolstykh, Lee, Vafai et al.: "Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits." in: The EMBO journal, Vol. 19, Issue 21, pp. 5682-91, 2000 (PubMed).

Catalog No. ABIN363065
$187.00
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