Protein Phosphatase 2, Catalytic Subunit, alpha Isozyme (PPP2CA) (N-Term) antibody

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Antigen
  • pp2ac
  • Ppp2ca
  • zgc:110641
  • PP2A
  • R75353
  • PP2Ac
  • PP2CA
  • PP2Calpha
  • RP-C
  • Pp2a1
  • PPP2CA
  • protein phosphatase 2, catalytic subunit, alpha isozyme
  • zgc:56064
  • protein phosphatase 2, catalytic subunit, beta isozyme
  • protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
  • ppp2ca
  • zgc:56064
  • ppp2cb
  • PPP2CA
  • Ppp2ca
  • PPP2CB
Alternatives
anti-Human Protein Phosphatase 2, Catalytic Subunit, alpha Isozyme antibody for Immunoprecipitation
Epitope
N-Term
18
18
14
11
10
7
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
129
103
80
17
13
11
8
7
6
5
5
4
3
3
3
1
1
1
1
1
Host
Rabbit
114
23
4
4
3
Clonality
Polyclonal
Conjugate
Un-conjugated
5
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
126
49
32
29
18
14
13
7
2
2
1
Options
Supplier
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Immunogen peptide Corresponding to the amino terminal sequence derived from human PP2A-a. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Isotype IgG
Specificity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.
Alternative Name PP2A-alpha (PPP2CA Antibody Abstract)
Background The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Molecular Weight 40 kDa
UniProt P67775
Pathways PI3K-Akt Signaling, Mitotic G1-G1/S Phases, Hepatitis C, Toll-Like Receptors Cascades
Application Notes Western blotting: 1:500-1:1000
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Product cited in: Ma, Li, Wang, Gong, Zhang, Li, Ji, Liu, Chen, Xiang: "Atrial natriuretic peptide suppresses Th17 development through regulation of cGMP-dependent protein kinase and PI3K-Akt signaling pathways." in: Regulatory peptides, Vol. 181, pp. 9-16, 2013 (PubMed).

Background publications Yu, Du, Moreno, Green, Ogris, Feng, Chou, McQuoid, Pallas: "Methylation of the protein phosphatase 2A catalytic subunit is essential for association of Balpha regulatory subunit but not SG2NA, striatin, or polyomavirus middle tumor antigen." in: Molecular biology of the cell, Vol. 12, Issue 1, pp. 185-99, 2001 (PubMed).

Janssens, Goris: "Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling." in: The Biochemical journal, Vol. 353, Issue Pt 3, pp. 417-39, 2001 (PubMed).

Tolstykh, Lee, Vafai, Stock: "Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits." in: The EMBO journal, Vol. 19, Issue 21, pp. 5682-91, 2000 (PubMed).

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