Transferrin Receptor antibody

Catalog No. ABIN370996

Product Details anti-Transferrin Receptor Antibody

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This Transferrin Receptor antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Functional Studies (Func)

Specificity: This antibody recognises CD71/Transferrin Receptor, Mr 180-190 kDa (90-95 kDa under reducing conditions). RI7217 inhibits cell proliferation in vitro. (Ref.2)

Characteristics: Synonyms: TfR1, p90, Transferrin receptor protein 1

Endotoxin Level: Low Endotoxin

Clone: RI7217

Isotype: IgG2a

Application Details

Application Notes: Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS without preservatives.

Preservative: Without preservative

Storage: -20 °C

Storage Comment: Store the antibody undiluted (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for Transferrin Receptor

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Alternative Name: CD71 / TFRC (TFRC Products)

Synonyms: Trfr antibody, LOC100219280 antibody, tfr antibody, cd71 antibody, tfr1 antibody, trfr antibody, CD71 antibody, T9 antibody, TFR antibody, TFR1 antibody, TR antibody, TRFR antibody, p90 antibody, 2610028K12Rik antibody, AI195355 antibody, AI426448 antibody, AU015758 antibody, E430033M20Rik antibody, Mtvr-1 antibody, Mtvr1 antibody, transferrin receptor antibody, TFRC antibody, Tfrc antibody, tfrc antibody

Background: CD71, a type II transmembrane glycoprotein expressed on the cell surface as a homodimer, is the Transferrin Receptor. It is essential for the growth of normal and neoplastic cells. (Ref.1,4) It is expressed at low levels on resting B and T lymphocytes but is upregulated during responses to antigens and mitogens, presumably reflecting the iron dependence of proliferation. (Ref.4) Its expression declines with maturation and differentiation. CD71 plays a critical role in cell proliferation by controlling the supply of iron, which is essential for many metabolic pathways, through the binding and endocytosis of transferrin, the major ironcarrying protein. It may also be involved in signal transduction via its association with the T cell receptor zeta chain.Synonyms: TfR1, Transferrin receptor protein 1, p90

Gene ID: 22042

UniProt: Q62351

Pathways: Transition Metal Ion Homeostasis