CTLA4 antibody (Cytotoxic T-Lymphocyte-Associated Protein 4)

Details for Product anti-CTLA4 Antibody No. ABIN371058, Supplier: Log in to see
Antigen
  • CTLA-4
  • CTLA4
  • CD152
  • Cd152
  • Ctla-4
  • Ly-56
  • CD
  • CELIAC3
  • GRD4
  • GSE
  • IDDM12
  • sCTLA4
  • cytotoxic T-lymphocyte-associated protein 4 precursor
  • cytotoxic T-lymphocyte-associated protein 4
  • CTLA-4
  • CTLA4
  • LOC100222727
  • Ctla4
Reactivity
Mouse (Murine)
229
213
83
19
2
2
Host
Hamster
215
80
79
40
27
5
3
Clonality (Clone)
Monoclonal ()
Conjugate
This CTLA4 antibody is un-conjugated
54
36
36
14
11
8
8
7
7
7
6
6
5
5
5
5
5
4
4
3
3
2
2
2
2
2
1
Application
Functional Studies (Func), Flow Cytometry (FACS), Immunoprecipitation (IP)
285
190
172
68
62
61
56
20
16
12
11
9
7
5
4
4
4
4
3
2
2
2
2
2
1
1
1
Options
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Clone 1B8
Isotype IgG
Specificity This Monoclonal antibody is specific to CD152/CTLA-4.
Characteristics Synonyms: CTLA-4, Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4
Purification Purified
Alternative Name CD152 / CTLA4 (CTLA4 Antibody Abstract)
Background The lymphocyte surface antigen CD152, also known as CTLA-4, is related to the co-stimulatory molecule CD28, and both molecules share common B7 family counter-receptors. (Ref.1-4) However CD152 is thought to be a negative regulator of T cell activation (Ref.1-3) and may play a role in apoptotic control of T cells. CD152 exists as a 69 kDa homodimer (Ref.1), and is relatively conserved among Humans, Mice and Chickens. (Ref.2)Synonyms: CTLA-4, Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4
Gene ID 100505288
UniProt P09793
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry. (Ref.1,2)Immunoprecipitation. In vitro Functional Studies. (Ref.1,2)Enhancement of tumor immunity. (Ref.3)
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer 100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Perkins, Wang, Donovan, He, Mark, Guan, Wang, Walunas, Bluestone, Listman, Finn: "Regulation of CTLA-4 expression during T cell activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 156, Issue 11, pp. 4154-9, 1996 (PubMed).

Leach, Krummel, Allison: "Enhancement of antitumor immunity by CTLA-4 blockade." in: Science (New York, N.Y.), Vol. 271, Issue 5256, pp. 1734-6, 1996 (PubMed).

Walunas, Lenschow, Bakker, Linsley, Freeman, Green, Thompson, Bluestone: "CTLA-4 can function as a negative regulator of T cell activation." in: Immunity, Vol. 1, Issue 5, pp. 405-13, 1995 (PubMed).

Freeman, Lombard, Gimmi, Brod, Lee, Laning, Hafler, Dorf, Gray, Reiser: "CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 149, Issue 12, pp. 3795-801, 1993 (PubMed).