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Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) antibody

Details for Product No. ABIN371058
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Antigen
Synonyms CTLA-4, CTLA4, CD152, Cd152, Ctla-4, Ly-56, CD, CELIAC3, GRD4, GSE, IDDM12, sCTLA4
Reactivity
Mouse (Murine)
(121), (97), (74), (17), (17)
Host
Hamster
(101), (64), (57), (4), (1), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(28), (27), (20), (4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Application
Functional Studies (Func), Immunoprecipitation (IP), Flow Cytometry (FACS)
(146), (61), (61), (28), (24), (20), (18), (15), (12), (12), (10), (2), (2), (1), (1)
Pubmed 4 references available
Quantity 0.5 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN371058
308.00 $
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Clone 1B8
Isotype IgG
Characteristics Synonyms: CTLA-4, Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4
Purification Purified
Alternative Name CD152 / CTLA4
Background The lymphocyte surface antigen CD152, also known as CTLA-4, is related to theco-stimulatory molecule CD28, and both molecules share common B7 familycounter-receptors. (Ref. 1-4) However CD152 is thought to be a negative regulator of T cellactivation (Ref. 1-3) and may play a role in apoptotic control of T cells. CD152 exists as a 69kDa homodimer (Ref. 1), and is relatively conserved among Humans, Mice and Chickens. (Ref. 2)
UniProt P09793
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry. (Ref.1,2)Immunoprecipitation. (Ref.1)In vitro Functional Studies. (Ref.1,2)Enhancement of tumor immunity. (Ref.3)Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer 100 mM Borate Buffered Saline, pH 8.2.No preservatives or amine-containing buffer salts added.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Freeman, Lombard, Gimmi et al.: "CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 149, Issue 12, pp. 3795-801, 1993 (PubMed).

Walunas, Lenschow, Bakker et al.: "CTLA-4 can function as a negative regulator of T cell activation." in: Immunity, Vol. 1, Issue 5, pp. 405-13, 1995 (PubMed).

Leach, Krummel, Allison: "Enhancement of antitumor immunity by CTLA-4 blockade." in: Science (New York, N.Y.), Vol. 271, Issue 5256, pp. 1734-6, 1996 (PubMed).

Perkins, Wang, Donovan et al.: "Regulation of CTLA-4 expression during T cell activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 156, Issue 11, pp. 4154-9, 1996 (PubMed).

Validation Images
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