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CTLA4 antibody

CTLA4 Reactivity: Mouse FACS, IP, Func Host: Hamster Monoclonal 1B8 unconjugated
Catalog No. ABIN371058
  • Target See all CTLA4 Antibodies
    CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
    Reactivity
    • 92
    • 60
    • 35
    • 5
    • 4
    Mouse
    Host
    • 63
    • 47
    • 13
    • 10
    • 1
    • 1
    Hamster
    Clonality
    • 77
    • 55
    • 2
    Monoclonal
    Conjugate
    • 64
    • 15
    • 13
    • 12
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CTLA4 antibody is un-conjugated
    Application
    • 80
    • 66
    • 53
    • 34
    • 17
    • 17
    • 14
    • 13
    • 10
    • 7
    • 7
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    Flow Cytometry (FACS), Immunoprecipitation (IP), Functional Studies (Func)
    Specificity
    This Monoclonal antibody is specific to CD152/CTLA-4.
    Characteristics
    Synonyms: CTLA-4, Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4
    Purification
    Purified
    Clone
    1B8
    Isotype
    IgG
  • Application Notes
    Flow Cytometry. (Ref.1,2)Immunoprecipitation. In vitro Functional Studies. (Ref.1,2)Enhancement of tumor immunity. (Ref.3)
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
    Shelf life: one year from despatch.
    Expiry Date
    12 months
  • Target
    CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
    Alternative Name
    CD152 / CTLA4 (CTLA4 Products)
    Synonyms
    CTLA-4 antibody, CTLA4 antibody, CD152 antibody, Cd152 antibody, Ctla-4 antibody, Ly-56 antibody, CD antibody, CELIAC3 antibody, GRD4 antibody, GSE antibody, IDDM12 antibody, sCTLA4 antibody, cytotoxic T-lymphocyte associated protein 4 antibody, cytotoxic T-lymphocyte-associated protein 4 antibody, CTLA4 antibody, Ctla4 antibody
    Background
    The lymphocyte surface antigen CD152, also known as CTLA-4, is related to the co-stimulatory molecule CD28, and both molecules share common B7 family counter-receptors. (Ref.1-4) However CD152 is thought to be a negative regulator of T cell activation (Ref.1-3) and may play a role in apoptotic control of T cells. CD152 exists as a 69 kDa homodimer (Ref.1), and is relatively conserved among Humans, Mice and Chickens. (Ref.2)Synonyms: CTLA-4, Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4
    Gene ID
    100505288
    UniProt
    P09793
    Pathways
    Cancer Immune Checkpoints
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