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Transferrin Receptor (p90, CD71) (TFRC) antibody (Biotin)

Details for Product No. ABIN371562, Supplier: Log in to see
Antigen
  • TFRC
  • tfr
  • cd71
  • tfr1
  • trfr
  • LOC100219280
  • 2610028K12Rik
  • AI195355
  • AI426448
  • AU015758
  • CD71
  • E430033M20Rik
  • Mtvr-1
  • Mtvr1
  • TFR
  • TFR1
  • TR
  • Trfr
  • p90
  • T9
  • TRFR
  • transferrin receptor (p90, CD71)
  • transferrin receptor
  • TFRC
  • tfrc
  • LOC100219280
  • Tfrc
Alternatives
anti-Human Transferrin Receptor (p90, CD71) antibody for Immunocytochemistry
Reactivity
Human
291
118
34
11
4
4
4
4
4
2
2
2
Host
Mouse
235
87
72
9
Clonality (Clone)
Monoclonal ()
Conjugate
Biotin
60
48
37
18
7
5
4
4
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
271
128
88
84
58
44
35
18
16
11
7
5
4
3
3
2
2
1
1
1
1
1
1
Options
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Clone RVS10
Isotype IgG1
Characteristics Synonyms: TfR1, p90, Transferrin receptor protein 1
Alternative Name CD71 / TFRC (TFRC Antibody Abstract)
Background The Transferrin Receptor has been structurally characterized as a sulfide bound dimer of identical glycoprotein subunits of 95 kDa. The transferrin receptor is not present on resting blood lymphocytes. On PBL, the receptor appears after activation. The expression of transferrin receptor is coordinately regulated with cell growth. Present on T and B cell lines. The soluble (or serum) transferrin receptor (sTfR) is a circulating truncated form of the membrane receptor protein, it is an 85 kDa glycoprotein forming in serum a 320 kDa complex with diferric transferrin. The most important clinical use of the sTfR determination is in the differential diagnosis between iron deficiency anaemia and the anaemia of chronic disease. CD71 plays a critical role in cell proliferation by controlling the supply of iron, which is essential for many metabolic pathways, through the binding and endocytosis of transferrin. (Ref.1-4)Synonyms: TfR1, Transferrin receptor protein 1, p90
UniProt P02786
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways Transition Metal Ion Homeostasis
Application Notes Flow Cytometry: 10 μL/10^6 cells.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.09 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or in (aliquots) at -20 °C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Hentze, Kühn: "Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 16, pp. 8175-82, 1996 (PubMed).

Trowbridge, Collawn, Hopkins: "Signal-dependent membrane protein trafficking in the endocytic pathway." in: Annual review of cell biology, Vol. 9, pp. 129-61, 1994 (PubMed).

Testa, Pelosi, Peschle: "The transferrin receptor." in: Critical reviews in oncogenesis, Vol. 4, Issue 3, pp. 241-76, 1993 (PubMed).