Transferrin Receptor (p90, CD71) (TFRC) antibody

Details for Product No. ABIN371565
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Antigen
Synonyms TFRC, tfr, cd71, tfr1, trfr, LOC100219280, 2610028K12Rik, AI195355, AI426448, AU015758, CD71, E430033M20Rik, Mtvr-1, Mtvr1, TFR, TFR1, TR, Trfr, p90, T9, TRFR
Reactivity
Human
(196), (110), (19), (11), (1), (1), (1)
Host
Mouse
(153), (86), (54), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(40), (33), (29), (8), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS)
(209), (75), (59), (58), (34), (25), (16), (13), (11), (10), (5), (4), (4), (3), (2), (1), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN371565
198.00 $
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Clone RVS10
Isotype IgG1
Characteristics Synonyms: TfR1, p90, Transferrin receptor protein 1
Purification Purified
Alternative Name CD71 / TFRC
Background The Transferrin Receptor has been structurally characterized as a sulfide bound dimer of identical glycoprotein subunits of 95 kDa. The transferrin receptor is not present on resting blood lymphocytes. On PBL, the receptor appears after activation. The expression of transferrin receptor is coordinately regulated with cell growth. Present on T and B cell lines. The soluble (or serum) transferrin receptor (sTfR) is a circulating truncated form of the membrane receptor protein, it is an 85 kDa glycoprotein forming in serum a 320 kDa complex with diferric transferrin. The most important clinical use of the sTfR determination is in the differential diagnosis between iron deficiency anaemia and the anaemia of chronic disease. CD71 plays a critical role in cell proliferation by controlling the supply of iron, which is essential for many metabolic pathways, through the binding and endocytosis of transferrin. (Ref.1-4)Synonyms: TfR1, Transferrin receptor protein 1, p90
UniProt P02786
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry: < / = 1 μg/10^6 cells.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer 100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Trowbridge, Collawn, Hopkins: "Signal-dependent membrane protein trafficking in the endocytic pathway." in: Annual review of cell biology, Vol. 9, pp. 129-61, 1994 (PubMed).

Testa, Pelosi, Peschle: "The transferrin receptor." in: Critical reviews in oncogenesis, Vol. 4, Issue 3, pp. 241-76, 1993 (PubMed).

Hentze, Kühn: "Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 16, pp. 8175-82, 1996 (PubMed).

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