Keratin 18 (KRT18) (N-Term) antibody

Details for Product No. ABIN371615
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Antigen
Synonyms krt18, MGC64569, MGC75922, KRT18, CYK18, K18, CK18, Krt1-18, DreK18, cb83, dapk1, sb:cb83, wu:fa13f02, wu:fb36b04, krtt1c6, zgc:66015
Epitope
N-Term
(41), (18), (16), (12), (12), (8), (7), (6), (6), (6), (5), (4), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
(433), (113), (105), (44), (38), (36), (29), (12), (12), (9), (7), (6), (5), (4), (4), (4), (3), (2), (2), (1), (1)
Host
Mouse
(248), (216), (9), (4), (3), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(31), (28), (8), (5), (5), (5), (5), (5), (5), (5), (5), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), ELISA, Western Blotting (WB)
(334), (199), (131), (127), (104), (100), (88), (72), (50), (43), (10), (5), (3), (1), (1)
Pubmed 7 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN371615
286.00 $
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Immunogen Recombinant N-terminal fragment of keratin 18.
Clone SB38b
Isotype IgG2b
Characteristics Synonyms: Cytokeratin-18, CK18, Keratin-18, Keratin 18, KRT18, CYK18, K18, Cell proliferation-inducinggene 46 protein, Keratin type I cytoskeletal 18
Purification Purified
Alternative Name Cytokeratin 18
Background Keratins are a family of intermediate filament proteins that assemble into filamentsthrough forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin(keratins 1-8). The two keratin types share only 30% sequence homology. (Ref. 1-6) Keratinsdemonstrate tissue- and differentiation-specific expression profiles. Cytokeratin 18, alsoknown as keratin 18, is a type I intermediate filament protein of approximately 48 kDa. Itexists as a heterotetramer composed of two type I and two type II keratins. Cytokeratin 18is expressed in all simple type epithelia and basal cells of many squamous andnon-epidermal epithelia, and is often co-expressed with cytokeratin 8. (Ref. 6-8) Tissuesfrom the gastrointestinal tract, respiratory tract and urogenital tract, as well as endocrineand exocrine tissues and mesothelial cells are positive for cytokeratin 18.
UniProt P05783
Research Area Signaling, Cytoskeleton, Extracellular Matrix
Application Notes ELISA: 1/5,000-1/20,000. Western Blot: 1/2,000-1/4,000. Immunohistochemistry (Acetone-Fixed, Frozen Tissue Sections): 10 µg/mlOther applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.1 mg/mL
Buffer 100 mM Borate buffered saline, pH 8.0 without preservatives or amine-containing buffer salts.
Preservative Without preservative
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C. Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Kulesh, Oshima: "Complete structure of the gene for human keratin 18." in: Genomics, Vol. 4, Issue 3, pp. 339-47, 1989 (PubMed).

Steinert, Roop: "Molecular and cellular biology of intermediate filaments." in: Annual review of biochemistry, Vol. 57, pp. 593-625, 1988 (PubMed).

Fuchs, Coppock, Green et al.: "Two distinct classes of keratin genes and their evolutionary significance." in: Cell, Vol. 27, Issue 1 Pt 2, pp. 75-84, 1982 (PubMed).

Tseng, Jarvinen, Nelson et al.: "Correlation of specific keratins with different types of epithelial differentiation: monoclonal antibody studies." in: Cell, Vol. 30, Issue 2, pp. 361-72, 1983 (PubMed).

Hanukoglu, Fuchs: "The cDNA sequence of a Type II cytoskeletal keratin reveals constant and variable structural domains among keratins." in: Cell, Vol. 33, Issue 3, pp. 915-24, 1983 (PubMed).

Schiller, Franke, Geiger: "A subfamily of relatively large and basic cytokeratin polypeptides as defined by peptide mapping is represented by one or several polypeptides in epithelial cells." in: The EMBO journal, Vol. 1, Issue 6, pp. 761-9, 1984 (PubMed).

Ku, Darling, Krams et al.: "Keratin 8 and 18 mutations are risk factors for developing liver disease of multiple etiologies." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 10, pp. 6063-8, 2003 (PubMed).

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