Keratin 19 (KRT19) (C-Term) antibody

Details for Product No. ABIN371616, Supplier: Log in to see
Antigen
  • k19
  • ck19
  • k1cs
  • krt9
  • krt15
  • MGC76282
  • MGC83069
  • KRT19
  • CK19
  • K19
  • K1CS
  • GK-19
  • Ka19
  • Krt1-19
  • AI663979
  • EndoC
  • Krt-1.19
  • keratin 19
  • KRT19
  • krt19
  • Krt19
Epitope
C-Term
133
77
48
34
22
19
16
16
13
10
9
8
8
8
7
7
6
6
5
5
4
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Mammalian
900
210
135
19
18
15
11
9
7
5
5
4
3
3
2
2
1
1
1
1
1
Host
Mouse
673
220
24
5
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
50
32
28
20
17
17
17
17
17
16
16
16
15
15
15
15
13
7
7
6
4
3
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
627
469
325
315
306
293
232
182
107
19
14
12
11
10
3
2
2
1
1
1
1
1
1
1
1
Options
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Immunogen Recombinant C-terminal keratin 19.
Clone SB39g
Isotype IgG2a
Specificity This antibody reacts specifically specifically with cytokeratin 19 and recombinant C-terminal keratin 19. Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification. The degree of cytokeratin 19 positivity in breast cancer distinguishes malignant from benign tumors. Cytokeratin 19 is also associated with malignant transformation in esophageal and pancreatic cancers. (Ref.8,9)
Characteristics Synonyms: Cytokeratin-19, Keratin-19, KRT19, CK19, K19, Keratin type I cytoskeletal 19
Purification Purified
Alternative Name Cytokeratin 19 (KRT19 Antibody Abstract)
Background Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1-8). The two keratin types share only 30 % sequence homology. (Ref.1-5) Keratins demonstrate tissue- and differentiation-specific expression profiles. Cytokeratin 19 is the smallest human keratin, is found in many simple and some non-keratinizing stratified squamous epithelia, and is often co-expressed with keratin 7.(Ref.6,7) Cytokeratin 19 has been implicated as a marker for stem cells in some tissues, such as hair follicles in the skin.Synonyms: CK19, Cytokeratin-19, K19, KRT19, Keratin type I cytoskeletal 19, Keratin-19
Gene ID 3880
UniProt P08727
Research Area Signaling, Cytoskeleton, Cytokeratins, Extracellular Matrix
Application Notes ELISA. Western Blot: 1/2,000-1/4,000. Immunohistochemistry (Acetone-Fixed, Frozen Tissue Sections): 10 μg/mL
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer 100 mM Borate buffered saline, pH 8.0 without preservatives or amine-containing buffer salts.
Preservative Without preservative
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
Immunofluorescence (IF) image for anti-Keratin 19 (KRT19) (C-Term) antibody (ABIN371616) anti-Keratin 19 (KRT19) (C-Term) antibody
Background publications Wu, Nishioka, Fujita, Murota, Ohtsuki, Ishida, Kuriyama: "Expression of cytokeratin 19 in human hepatocellular carcinoma cell lines." in: International journal of oncology, Vol. 20, Issue 1, pp. 31-7, 2001 (PubMed).

Bosch, Leube, Achtstätter, Moll, Franke: "Expression of simple epithelial type cytokeratins in stratified epithelia as detected by immunolocalization and hybridization in situ." in: The Journal of cell biology, Vol. 106, Issue 5, pp. 1635-48, 1988 (PubMed).

Schiller, Franke, Geiger: "A subfamily of relatively large and basic cytokeratin polypeptides as defined by peptide mapping is represented by one or several polypeptides in epithelial cells." in: The EMBO journal, Vol. 1, Issue 6, pp. 761-9, 1984 (PubMed).

Franke, Schiller, Hatzfeld, Winter: "Protein complexes of intermediate-sized filaments: melting of cytokeratin complexes in urea reveals different polypeptide separation characteristics." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 80, Issue 23, pp. 7113-7, 1984 (PubMed).

Hanukoglu, Fuchs: "The cDNA sequence of a Type II cytoskeletal keratin reveals constant and variable structural domains among keratins." in: Cell, Vol. 33, Issue 3, pp. 915-24, 1983 (PubMed).

Tseng, Jarvinen, Nelson, Huang, Woodcock-Mitchell, Sun: "Correlation of specific keratins with different types of epithelial differentiation: monoclonal antibody studies." in: Cell, Vol. 30, Issue 2, pp. 361-72, 1983 (PubMed).

Moll, Franke, Schiller, Geiger, Krepler: "The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells." in: Cell, Vol. 31, Issue 1, pp. 11-24, 1983 (PubMed).

Fuchs, Coppock, Green, Cleveland: "Two distinct classes of keratin genes and their evolutionary significance." in: Cell, Vol. 27, Issue 1 Pt 2, pp. 75-84, 1982 (PubMed).