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THRA antibody (N-Term)
THRA
Reactivity: Human, Mouse, Rat, Dog
WB
Host: Mouse
Monoclonal
2103
unconjugated
Product Details anti-THRA Antibody
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Target
See all THRA Antibodies
THRA
(Thyroid Hormone Receptor, alpha (THRA))
Binding Specificity
All epitopes for THRA antibodies
N-Term
Reactivity
All reactivities for THRA antibodies
Human, Mouse, Rat, Dog
Host
All hosts for THRA antibodies
Mouse
Clonality
All clonalities for THRA antibodies
Monoclonal
Conjugate
All conjugates for THRA antibodies
This THRA antibody is un-conjugated
Application
All applications for THRA antibodies
Western Blotting (WB)
Specificity
AM08268PU-N is specific for the ~50k THR alpha-1 and the ~58k THR alpha-2 proteins.
Cross-Reactivity (Details)
Species reactivity (expected):Canine (Dog), Mouse and Rat. Species reactivity (tested):Human.
Characteristics
Synonyms: Thyroid hormone receptor alpha, THRA1, THRA2, C-erbA-alpha, c-erbA-1, EAR-7, EAR7,NR1A1, Nuclear receptor subfamily 1 group A member 1
Purification
Prepared from Mouse Ascites by Ammonium Sulfate Precipitation followed by Affinity Chromatography on Protein G.
Immunogen
Peptide corresponding to amino acid residues from the N-terminal region of human thyroidhormone receptor, alpha1/alpha2-isotype.
Clone
2103
Isotype
IgG1
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Discover our top product THRA Primary Antibody
Alternatives
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Application Details
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Application Notes
Western Blot: 1/1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
Storage
-20 °C
Storage Comment
Store the antibody undiluted (in aliquots) at -20 °C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Expiry Date
12 months
Target Details for THRA
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Target
THRA
(Thyroid Hormone Receptor, alpha (THRA))
Alternative Name
THRA / ERBA1 (THRA Products )
Synonyms
AR7 antibody, CHNG6 antibody, EAR7 antibody, ERB-T-1 antibody, ERBA antibody, ERBA1 antibody, NR1A1 antibody, THRA1 antibody, THRA2 antibody, c-ERBA-1 antibody, C-ERBA-ALPHA antibody, TRalpha antibody, c-erba antibody, erba antibody, nr1a1-A antibody, thra-A antibody, thra1 antibody, TR[a]1 antibody, nr1a1 antibody, thra antibody, thral antibody, tra antibody, tra1 antibody, wu:fb59g07 antibody, Thra1 antibody, 6430529J03Rik antibody, AW259572 antibody, Erba antibody, Nr1a1 antibody, Rvr antibody, T3R[a] antibody, T3Ralpha antibody, Thra2 antibody, C-ERBA ALPHA1 antibody, Thra antibody, fTHRalphaA antibody, nr1a1-a antibody, thyroid hormone receptor, alpha antibody, thyroid hormone receptor, alpha L homeolog antibody, thyroid hormone receptor alpha a antibody, thyroid hormone receptor alpha antibody, thyroid hormone receptor alpha-A antibody, THRA antibody, thra.L antibody, thraa antibody, Thra antibody, tr-alpha antibody, LOC109641414 antibody
Background
Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005, Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TR-alpha1, TR-alpha2, TR-beta1 and TR-beta2. TR-alpha1, TR-beta1 and TR-beta2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005).Synonyms: C-erbA-alpha, EAR-7, EAR7, NR1A1, Nuclear receptor subfamily 1 group A member 1, THRA1, THRA2, Thyroid hormone receptor alpha, c-erbA-1
Gene ID
7067
UniProt
P10827
Pathways
Nuclear Receptor Transcription Pathway , Steroid Hormone Mediated Signaling Pathway , Sensory Perception of Sound , Cellular Response to Molecule of Bacterial Origin , Regulation of Lipid Metabolism by PPARalpha , Regulation of Muscle Cell Differentiation , Maintenance of Protein Location , Skeletal Muscle Fiber Development
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