MUC1 antibody (C-Term)

Catalog No. ABIN371859

Product Details anti-MUC1 Antibody

Target: MUC1 (Mucin 1 (MUC1))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This MUC1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody recognizes Mucin 1 (MUC1/CA15-3/CA27-29).

Cross-Reactivity (Details): Species reactivity (tested):Human.

Characteristics: Synonyms: MUC-1, PEMT, Episialin, EMA, H23AG, PUM, DF3, CA 15-3, Polymorphic epithelial mucin,Tumor-associated mucin, Carcinoma-associated mucin, Tumor-associated epithelialmembrane antigen, Peanut-reactive urinary mucin, Breast carcinoma-associated antigenDF3

Purification: Purified

Immunogen: Synthetic Peptide derived from C-terminal sequence of Human CD227/Mucin-1.

Clone: G22-L

Isotype: Ig Fraction

Application Details

Application Notes: Immunohistochemistry on Paraffin Sections: 10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 20 mM Tris-HCl, pH 8.0 containing 20 mg/mL BSA as stabilizer and 0.05 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

References for anti-MUC1 antibody (ABIN371859)

Szlendak, Sitarz, Berbecka, Mielko, Morsink, Maciejewski, Offerhaus, Polkowski: "Expression of cyclooxygenase-2 and mucin 1 in colorectal cancer." in: Molecular and clinical oncology, Vol. 13, Issue 5, pp. 52, (2020) (PubMed).

Margarit, Taylor, Roberts, Hopkins, Davies, Brenton, Conlan, Bunkheila, Joels, White, Gonzalez: "MUC1 as a discriminator between endometrium from fertile and infertile patients with PCOS and endometriosis." in: The Journal of clinical endocrinology and metabolism, Vol. 95, Issue 12, pp. 5320-9, (2011) (PubMed).

Target Details for MUC1

Target: MUC1 (Mucin 1 (MUC1))

Alternative Name: CD227 / Mucin-1 / MUC1 (MUC1 Products)

Synonyms: CA 15-3 antibody, CD227 antibody, EMA antibody, H23AG antibody, KL-6 antibody, MAM6 antibody, MCKD1 antibody, MUC-1 antibody, MUC-1/SEC antibody, MUC-1/X antibody, MUC1/ZD antibody, PEM antibody, PEMT antibody, PUM antibody, Muc-1 antibody, mucin 1, cell surface associated antibody, mucin 1, transmembrane antibody, MUC1 antibody, Muc1 antibody

Background: MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed abundantly in >90 % breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells. Isoform 7 of MUC1 behaves as a receptor and binds the secreted isoform 5. The binding induces the phosphorylation of the isoform 7, alters cellular morphology and initiates cell signaling.Synonyms: Breast carcinoma-associated antigen DF3, CA 15-3, Carcinoma-associated mucin, DF3, EMA, Episialin, H23AG, MUC-1, PEMT, PUM, Peanut-reactive urinary mucin, Polymorphic epithelial mucin, Tumor-associated epithelial membrane antigen, Tumor-associated mucin

Gene ID: 4582

UniProt: P15941

Pathways: Negative Regulation of intrinsic apoptotic Signaling