SORL1 antibody (C-Term)

Catalog No. ABIN374076

Product Details anti-SORL1 Antibody

Target: SORL1 (Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Dog

Host: Goat

Clonality: Polyclonal

Conjugate: This SORL1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: C-TGFSDDVPMV IA

Specificity: This antibody detects Sortilin-Related Receptor at C-term.

Cross-Reactivity (Details): Species reactivity (expected):Human, Rat, Canine (Dog), Bovine.
Species reactivity (tested):Mouse.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide from the C Terminus of the protein according to NP_003096.1. Genename: SORL1

Application Details

Application Notes: Peptide ELISA: Limit dilution 1: 32000. Western blot: 0.3-1 μg/mL. Approx 250 kDa band observed in Mouse and Rat Brain lysates(calculated MW of 240 kDa according to Human NP_003096.1, and 240 kDa accordnig toMouse NP_035566.2).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % Sodium Azide, pH 7.3 with 0.5 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for SORL1

Target: SORL1 (Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1))

Alternative Name: Sortilin-Related Receptor (SORL1) (SORL1 Products)

Synonyms: SORL1 antibody, C11orf32 antibody, LR11 antibody, LRP9 antibody, SORLA antibody, SorLA-1 antibody, gp250 antibody, SorLA antibody, 2900010L19Rik antibody, AI596264 antibody, AW261561 antibody, mSorLA antibody, Lr11 antibody, RGD619914 antibody, sortilin related receptor 1 antibody, sortilin-related receptor antibody, sortilin-related receptor, L(DLR class) A repeats containing antibody, sortilin-related receptor, L(DLR class) A repeats-containing antibody, sortilin-related receptor, LDLR class A repeats-containing antibody, sorl1 antibody, LOC582560 antibody, SORL1 antibody, Sorl1 antibody

Background: Sortilin-related receptor (SORL1) is likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. Expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole, low expression in the putamen and the thalamus. According to PubMed:9157966, found in spinal cord, testis, liver, kidney and pancreas with detectable levels in placenta, lung and heart. According to PubMed:8940146, expressed in the prostate, ovary, thyroid and spleen, but not found in kidney, liver, lung, skeletal muscle, bone marrow and adrenals.Synonyms: LR11, Low-density lipoprotein receptor relative with 11 ligand-binding repeats, SorLA, SorLA-1, Sorting protein-related receptor containing LDLR class A repeats

Gene ID: 6653

NCBI Accession: NP_003096

UniProt: Q92673

Pathways: Smooth Muscle Cell Migration