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Prostaglandin-Endoperoxide Synthase 1 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS1) (C-Term) antibody

Details for Product No. ABIN374151
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Antigen
Synonyms COX-1, cox-1, PTGS1, Ptgs1, COX1, Cox-1, Cox-3, PGHS-1, PHS 1, Pghs1, Cox1, Cox3, cox1, zCOX-1, COX3, PCOX1, PES-1, PGG/HS, PGHS1, PHS1, PTGHS, COX-3
Epitope
C-Term
(16), (10), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(80), (34), (27), (22), (14), (14), (12), (2), (2), (1), (1), (1), (1)
Host
Goat
(69), (23), (14)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(73), (37), (32), (16), (10), (10), (9), (5), (5), (4), (2), (2)
Pubmed 1 reference available
Quantity 0.1 mg
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Catalog No. ABIN374151
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Immunogen Peptide with sequence from the C Terminus of the protein sequence Genename: PTGS1
Sequence C-QDDGPAVERPSTEL
Specificity This antibody is expected to recognize both Human isoforms of COX1 according to NP_000953.2 and NP_542158.1. Species Reactivity: Tested: Human.
Purification Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
Alternative Name Cyclooxygenase 1
Background Cyclooxygenase (COX), also known as Prostaglandin H2 synthase and Prostaglandin endoperoxide synthase, is a key enzyme in the of conversion arachidonic acid to Prostaglandin H2. Prostaglandin H2 is converted by other enzymes into inflammatory mediators prostaglandin (PG) D2, PGE2, PGF2a, PGI2 and Thromboxane A2. Thus, COX is a key enzyme in the production of inflammatory agents and is the target of intense research and drug discovery activities. There are two enzymes of COX, COX 1 and COX 2. COX 1 is constitutively produced in many (most) cell types. It is important in the gut for the production of prostaglandins, which inhibit gastric secretion. It can be induced in monocytes, macrophages and other cells. It is induced as part of the inflammatory response by IL 1beta and other cytokines. It is induced by growth factors such as EGF and PDGF. Expression is inhibited by glucocorticosteroids such as cortisol and dexamethasone. Lipopolysaccharide in bacterial infections induces COX 2. COX 2 is also found in elevated levels in synoviocytes from rheumatoid arthritis patients. The discomforts of inflammation such as pain and swelling are largely due to the action of prostaglandins produced by COX2.
Alternate names: COX-1, COX1, Cyclooxygenase-1, PGH synthase 1, PGHS-1, PTGS1, Prostaglandin G/H synthase 1, Prostaglandin H2 synthase 1, Prostaglandin-endoperoxide synthase 1
Molecular Weight 64.5kDa (NP_542158.1) and 68.7kDa (NP_000953.2)
Gene ID 5742
NCBI Accession NP_000953.2
UniProt P23219
Application Notes Peptide ELISA: Limit dilution 1: 32000. Western blot: 1 - 3 µg/ml. Approx 65-70kDa bands seen in HeLa lysate. Immunohistochemistry on paraffin sections: 3 - 5 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris buffered saline, pH~7.3 containing 0.02% Sodium Azide as preservative and 0.5% BSA as stabilizer
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Prostaglandin-Endoperoxide Synthase 1 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS1) (C-Term) antibody anti-Prostaglandin-Endoperoxide Synthase 1 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS1) (C-Term) antibody
anti-Prostaglandin-Endoperoxide Synthase 1 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS1) (C-Term) antibody (2) anti-Prostaglandin-Endoperoxide Synthase 1 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS1) (C-Term) antibody (Image 2)
Background publications Yokoyama, Tanabe: "Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme." in: Biochemical and biophysical research communications, Vol. 165, Issue 2, pp. 888-94, 1990 (PubMed).

Validation Images
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