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BIRC5 antibody (Baculoviral IAP Repeat-Containing 5) (C-Term)

Details for Product anti-BIRC5 Antibody No. ABIN374456, Supplier: Log in to see
Antigen
  • AAC-11
  • AP14
  • API4
  • Api4
  • EPR-1
  • survivin40
  • TIAP
Alternatives
anti-Human BIRC5 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
C-Term
20
5
4
4
3
3
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
65
35
10
1
1
1
Host
Goat
58
22
2
Clonality
Polyclonal
Conjugate
This BIRC5 antibody is un-conjugated
2
2
2
Application
Western Blotting (WB)
59
25
20
14
13
7
6
3
2
2
1
1
1
Supplier
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Immunogen Peptide with sequence CVRRAIEQLAAMD, from the C Terminus of the protein sequence
Specificity This antibody reacts to Apoptosis inhibitor survivin.
Purification Affinity chromatography
Alternative Name IAP4 / BIRC5 (BIRC5 Antibody Abstract)
Background Survivin is an anti-apoptotic protein, expressed in the G2/M cell cycle phase. At the onset of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptotic function and increased caspase 3 activity. Survivin is also abundantly expressed in brain tissues (astrocytes and some neurons) of adult rats following traumatic brain injury. Survivin has been found co-expressed with NeuN (mature neuronal marker) and PCNA (a cell cycle protein. Survivin might affect regulation of neural cell proliferative responses after brain injury. Survivin is also an inhibitor of apoptosis (IAP), or programmed cell death, that is selectively overexpressed in common human cancers.Synonyms: API4, Apoptosis inhibitor 4, Apoptosis inhibitor survivin, Baculoviral IAP repeat-containing protein 5, Survivin
Gene ID 332
NCBI Accession NP_001012270
UniProt O15392
Research Area Cancer, Apoptosis/Necrosis, Neurology
Pathways Apoptosis, Cell Division Cycle
Application Notes Peptide ELISA: 1/16000. Western blot: 0.01 - 0.5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0,5 mg/mL
Buffer Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-BIRC5 antibody (Baculoviral IAP Repeat-Containing 5) (C-Term) (ABIN374456) anti-Baculoviral IAP Repeat-Containing 5 (BIRC5) (C-Term) antibody
Background publications Li, Ambrosini, Chu, Plescia, Tognin, Marchisio, Altieri: "Control of apoptosis and mitotic spindle checkpoint by survivin." in: Nature, Vol. 396, Issue 6711, pp. 580-4, 1999 (PubMed).