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GATA1 antibody (GATA Binding Protein 1 (Globin Transcription Factor 1)) (Internal Region)

Details for Product anti-GATA1 Antibody No. ABIN374593, Supplier: Log in to see
Antigen
  • GATA1
  • gata-1
  • Gata1
  • si:dkeyp-77f7.5
  • Gata-1
  • Gf-1
  • eryf1
  • Eryf1
  • ERYF1
  • GATA-1
  • GF-1
  • GF1
  • NF-E1
  • NFE1
  • XLANP
  • XLTDA
  • XLTT
Epitope
Internal Region
44
42
13
13
8
6
5
4
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
215
119
114
9
7
7
5
3
2
1
1
Host
Goat
175
30
15
Clonality
Polyclonal
Conjugate
This GATA1 antibody is un-conjugated
4
4
4
4
3
3
3
3
3
3
3
3
1
1
1
Application
Western Blotting (WB)
166
61
55
54
34
19
19
9
4
3
2
1
Supplier
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Immunogen Peptide with sequence C-DAEAYRHSPVFQ, from the internal region of the protein sequence
Specificity This antibody reacts to GATA1.
Cross-Reactivity (Details) Species reactivity (expected):Mouse, Rat, Canine, Bovine.
Species reactivity (tested):Human.
Purification Affinity chromatography
Alternative Name GATA1 (GATA1 Antibody Abstract)
Background GATA1 (Globin transcription factor 1) is a Cys2/Cys2 zinc finger DNA binding protein that is expressed primarily in erythroid, megakaryocytic, mast cells and eosinophilic cells. It belongs to the GATA family of transcription factors. GATA1 is a transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells. The protein also plays an important role in erythroid development by regulating the switch from fetal hemoglobin production to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. Acquired somatic mutations in GATA1 occur in virtually all children with Down's Syndrome, congenital transient myeloproliferative syndrome (TMD) and acute megakaryocytic leukemia.Synonyms: ERYF1, Eryf1, Erythroid transcription factor, GATA-1, GATA-binding factor 1, GF-1, GF1, NF-E1 DNA-binding protein
Gene ID 2623
NCBI Accession NP_002040
UniProt P15976
Research Area Organogenesis, Hematopoietic Progenitors, Transcription Factors
Pathways
Application Notes Peptide ELISA: 1/16000. Western Blot: 0.3 - 1.0 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0,5 mg/mL
Buffer Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-GATA1 antibody (GATA Binding Protein 1 (Globin Transcription Factor 1)) (Internal Region) (ABIN374593) anti-GATA Binding Protein 1 (Globin Transcription Factor 1) (GATA1) (Internal Region) antibody
Background publications Li, Godinho, Klusmann et al.: "Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1." in: Nature genetics, Vol. 37, Issue 6, pp. 613-9, 2005 (PubMed).