Zinc Metalloproteinase, Ste24 (Zmpste24) (C-Term) antibody

Details for Product No. ABIN374738
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Synonyms DDBDRAFT_0189115, DDBDRAFT_0237846, DDB_0189115, DDB_0237846, F2N1.21, F2N1_21, STE24, FACE-1, FACE1, HGPS, PRO1, Ste24p, A530043O15Rik, D030046F19, Face-1, MADB, fi45a02, wu:fi45a02, zgc:55655
(48), (14), (13), (10), (7), (6), (2), (2), (1), (1), (1)
(86), (9), (7), (1), (1)
(72), (14)
(9), (7), (7), (7), (6), (6), (2), (1), (1), (1), (1)
Western Blotting (WB)
(81), (47), (25), (9), (7), (2)
Pubmed 1 reference available
Quantity 0.1 mg
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Peptide with sequence C-ERLQALKTMKQH, from the C Terminus of the protein sequence
Specificity This antibody reacts to FACE1.
Purification Affinity chromatography
Alternative Name ZMPSTE24 (Zmpste24 Antibody Abstract)
Background The protein encoded by this gene is a zinc metalloprotease similar to yeast Ste24p. It is an integral membrane protein belonging to peptidase family M48 and is found in the endoplasmic reticulum and possibly in the Golgi compartment. It proteolytically removes the C-terminal three residues of farnesylated proteins, and acts on lamin A/C.Synonyms: CAAX prenyl protease 1 homolog, FACE-1, FACE1, Farnesylated proteins-converting enzyme 1, Prenyl protein-specific endoprotease 1, STE24, Zinc metalloproteinase Ste24 homolog
Gene ID 10269, 9606
UniProt O75844
Research Area Proteolysis / Ubiquitin, Cytoskeleton
Application Notes Peptide ELISA: 1/128000. Western Blot: 0.5 - 1.5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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Background publications Fong, Frost, Meta et al.: "A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria." in: Science (New York, N.Y.), Vol. 311, Issue 5767, pp. 1621-3, 2006 (PubMed).

Catalog No. ABIN374738
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