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IL12B antibody (Internal Region)

IL12B Reactivity: Mouse, Rat WB Host: Goat Polyclonal unconjugated
Catalog No. ABIN374932
  • Target See all IL12B Antibodies
    IL12B (Interleukin 12 beta (IL12B))
    Binding Specificity
    • 15
    • 12
    • 9
    • 8
    • 7
    • 6
    • 6
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 64
    • 41
    • 11
    • 9
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Mouse, Rat
    Host
    • 80
    • 20
    • 3
    • 2
    Goat
    Clonality
    • 83
    • 22
    Polyclonal
    Conjugate
    • 62
    • 9
    • 9
    • 6
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IL12B antibody is un-conjugated
    Application
    • 87
    • 58
    • 35
    • 17
    • 13
    • 13
    • 13
    • 9
    • 8
    • 7
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    C-EARQQNKYEN YS
    Specificity
    This antibody reacts to Il12b / Il12p40.
    Purification
    Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
    Immunogen
    Peptide with sequence from the internal region of the protein sequence according to NP_032378.1.
    Top Product
    Discover our top product IL12B Primary Antibody
  • Application Notes
    Peptide ELISA: 1/4000. Western Blot: 1 - 3 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Tris saline, pH ~7.3, 0.02 % Sodium Aazide, 0.5 % BSA
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    IL12B (Interleukin 12 beta (IL12B))
    Alternative Name
    Interleukin-12 beta / IL12B (IL12B Products)
    Synonyms
    CLMF antibody, CLMF2 antibody, IL-12B antibody, NKSF antibody, NKSF2 antibody, p40 antibody, Il-12b antibody, Il12p40 antibody, Il-12p40 antibody, Il12 antibody, IL-12p40 antibody, IL-12 antibody, IL-12 p40 antibody, il12b antibody, il12p40.b antibody, zgc:152789 antibody, IL-12.p40 antibody, IL12p40 antibody, IL12B antibody, CLMF p40 antibody, interleukin 12B antibody, interleukin 12b antibody, interleukin 12Ba antibody, IL12B antibody, Il12b antibody, il12ba antibody
    Background
    Interleukin 12 (IL12) can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine activated killer cells, and stimulate the production of IFN gamma by resting PBMC. IL12 induces IFN gamma, TNF alpha production in T and NK cells, costimulation of PBL proliferation, proliferation/differentiation of TH1 T lymphocytes. It is downregulated by IL10, homodimeric p40 antagonistic to functional p70 heterodimer. IL12R beta 1 binds p40 but when dimeric with IL12R beta 2 binds p35.Synonyms: CLMF p40, Cytotoxic lymphocyte maturation factor 40 kDa subunit, IL-12 subunit p40, IL-12B, Interleukin-12B, NK cell stimulatory factor chain 2, NKSF2
    Gene ID
    3593
    NCBI Accession
    NP_002178
    UniProt
    P29460
    Pathways
    JAK-STAT Signaling, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
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