TNFRSF10B antibody

Catalog No. ABIN376980

The Rabbit Polyclonal anti-TNFRSF10B antibody (ABIN376980) specifically detects TNFRSF10B in FACS. The antibody is reactive with Human samples.

Quick Overview for TNFRSF10B antibody (ABIN376980)

Target: TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNFRSF10B antibody is un-conjugated

Application: Flow Cytometry (FACS)

Product Details anti-TNFRSF10B Antibody

Specificity: Human DR5

Characteristics: Rabbit Anti-Human DR5-UNLB

Purification: Purified

Immunogen: Recombinant DR5

Isotype: IgG

Application Details

Application Notes:

• Applications: FC - Quality tested WB , ICC
• Working Dilutions: Flow Cytometry Purified (UNLB) antibody 3 g/106 cells For flow cytometry, the suggested use of these reagents is in a final volume of 100 L Immunoblotting Purified (UNLB) antibody 2 g/mL Immunocytochemistry Purified (UNLB) antibody 2 g/mL

Comment:

induction of apoptosis

Sample Volume: 0,2 mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: 0.1 mg of purified immunoglobulin in 0.2 mL of borate buffered saline,  pH 8.2. No preservatives or amine-containing buffer salts added

Preservative: Without preservative

Handling Advice: Each reagent is stable for the period shown on the bottle label if stored as directed.

Storage: 4 °C

Storage Comment: Store at 2-8°C

Target Details for TNFRSF10B

Target: TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))

Alternative Name: DR5

Background: DR5, also known as TRAIL-R2, TRICK2 and KILLER, is a widely expressed type I membrane member of the tumor necrosis (TNF) receptor family. Members of this family contain multiple cysteine-rich repeats in their extracellular domain and while the cytoplasmic region is less conserved, they do contain an intracellular 80 AA motif known as the ‘death domain' (DD). DR5 is a receptor for the cytotoxic ligand TRAIL which induces apoptosis and it is the cytoplasmic DD that is responsible for transducing the death process. DR5 has also been shown to activate NF- λB.

Pathways: p53 Signaling, Apoptosis, Positive Regulation of Endopeptidase Activity