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SET Domain Containing (Lysine Methyltransferase) 7 (SETD7) (AA 159-189), (Center) antibody

Details for Product No. ABIN387997
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Antigen
Epitope
AA 159-189, Center
(10), (7), (4), (3), (3), (2), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(62), (16), (15), (13), (12), (12), (1), (1)
Host
Rabbit
(42), (21)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(51), (30), (17), (10), (8), (6), (5), (2), (2)
Pubmed 4 references available
Quantity 400 µL
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Catalog No. ABIN387997
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Immunogen This SET7 (SET9) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 159-189 AA from the Central region of human SET7 (SET9).
Clone RB2763
Isotype Ig
Specificity This SET7 (SET9) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 167~196 amino acids from the center region of human SET9.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name SET7 (SET9)
Background Similar to acetylation and phosphorylation, histone methylation at the N-terminal tail has emerged as an important role in regulating chromatin dynamics and gene activity. Histone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET-domain-containing methyltransferase family. Five members have been identified in the arginine methyltransferase family. About 27 are grouped into the SET-domain family, and another 17 make up the PR domain family that is related to the SET domain family. The retinoblastoma protein-interacting zinc finger geneRIZ1 is a tumor suppressor gene and a FOUNDING member of the PR domain family. RIZ1 inactivation is commonly found in many types of human cancers and occurs through loss of mRNA expression, frame shift mutation, chromosomal deletion, and missense mutation. RIZ1 is also a tumor susceptibility gene in mice. The loss of RIZ1 mRNA in human cancers was shown to associate with DNA methylation of its promoter CpG island. Methylation of the RIZ1 promoter strongly correlated with lost or decreased RIZ1 mRNA expression in breast, liver, colon, and lung cancer cell lines as well as in liver cancer tissues.
Synonyms: KMT7
Molecular Weight 40721 DA
Gene ID 80854
UniProt Q8WTS6
Research Area Signaling, Protein Modifications, Cancer, Chromatin, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-SET Domain Containing (Lysine Methyltransferase) 7 (SETD7) (AA 159-189), (Center) antibody The anti-SET9 Ctr Pab (ABIN387997) is used in Western blot to detect SET9 in mouse brain tissue lysate.
anti-SET Domain Containing (Lysine Methyltransferase) 7 (SETD7) (AA 159-189), (Center) antibody (2) Western blot analysis of SET9(arrow) using rabbit polyclonal SET9 Antibody(ABIN387997). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the SET9 gene (Lane 2) (Origene Technologies).
anti-SET Domain Containing (Lysine Methyltransferase) 7 (SETD7) (AA 159-189), (Center) antibody (3) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
Background publications Nishioka, Chuikov, Sarma et al.: "Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation." in: Genes & development, Vol. 16, Issue 4, pp. 479-89, 2002 (PubMed).

Kwon, Chang, Kwak et al.: "Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9-AdoMet." in: The EMBO journal, Vol. 22, Issue 2, pp. 292-303, 2003 (PubMed).

Xiao, Jing, Wilson et al.: "Structure and catalytic mechanism of the human histone methyltransferase SET7/9." in: Nature, Vol. 421, Issue 6923, pp. 652-6, 2003 (PubMed).

Wysocka, Myers, Laherty et al.: "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1." in: Genes & development, Vol. 17, Issue 7, pp. 896-911, 2003 (PubMed).

Validation Images
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