Protein Inhibitor of Activated STAT, 4 (PIAS4) (N-Term), (AA 48-79) antibody

Details for Product No. ABIN388061
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

 
Antigen
Synonyms PIASY, Piasg, ZMIZ6, pias4, piasy, wu:fc54c11, wu:fi18c10, wu:fi20e09, wu:fk93f11, zgc:66410, piasg, zmiz6, Pias-gamma, LOC100219439
Epitope
N-Term, AA 48-79
(13), (6), (1), (1), (1), (1), (1)
Reactivity
Human
(40), (20), (12), (1), (1), (1), (1)
Host
Rabbit
(39), (1)
Clonality (Clone)
Polyclonal ()
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(40), (24), (15), (10), (1), (1), (1), (1)
Pubmed 3 references available
Catalog no. ABIN388061
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This PIASy antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-79 AA from the N-terminal region of human PIASy.
Clone RB0680
Isotype Ig
Specificity This PIASy antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56~86 amino acids from the N-terminal region of human PIASy1.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name PIASy
Background PIASy1 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. This protein plays a crucial role in transcriptional coregulation of various cellular pathways, including the STAT pathway, the p53 pathway, the wnt pathway and the steroid hormone signaling pathway. PIASy1 is involved in gene silencing, and promotes PARK7 sumoylation.
Synonyms: E3 SUMO-protein ligase PIAS4, Protein inhibitor of activated STAT protein 4, Protein inhibitor of activated STAT protein gamma, PIAS-gamma, PIASy, PIAS4, PIASG
Molecular Weight 56504 DA
Gene ID 51588
UniProt Q8N2W9
Research Area Apoptosis/Necrosis, Cell Signaling, Protein Modifications, Transcription Factors, Signaling, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Protein Inhibitor of Activated STAT, 4 (PIAS4) (N-Term), (AA 48-79) antibody The anti-PIASy polyclonal antibody (ABIN388061) is used in Western blot to detect PIASy in HL-60 cell lysate.
anti-Protein Inhibitor of Activated STAT, 4 (PIAS4) (N-Term), (AA 48-79) antibody (2) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
Background publications Liu, Liao, Rao et al.: "Inhibition of Stat1-mediated gene activation by PIAS1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 18, pp. 10626-31, 1998 (PubMed).

Liu, Gross, ten Hoeve et al.: "A transcriptional corepressor of Stat1 with an essential LXXLL signature motif." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 6, pp. 3203-7, 2001 (PubMed).

Imoto, Sugiyama, Muromoto et al.: "Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3." in: The Journal of biological chemistry, Vol. 278, Issue 36, pp. 34253-8, 2003 (PubMed).

Hosts (39), (1)
Reactivities (40), (20), (12), (1), (1), (1), (1)
Applications (40), (24), (15), (10), (1), (1), (1), (1)
Epitopes (13), (6), (1), (1), (1), (1), (1)
back to top