BID antibody (BH3 Interacting Domain Death Agonist) (AA 68-103)

Details for Product anti-BID Antibody No. ABIN388099, Supplier: Log in to see
Antigen
  • BID
  • bid
  • si:ch211-238n5.6
  • fp497
  • xbid
  • DKFZp469E066
  • FP497
  • 2700049M22Rik
  • AI875481
  • AU022477
  • BH3 interacting domain death agonist
  • BH3 interacting domain death agonist-like
  • BH3-interacting domain death agonist-like
  • BID
  • bida
  • bid
  • Bid
  • LOC100355991
  • LOC100730546
Alternatives
anti-Human BID antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
AA 68-103, BH3 Domain
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Reactivity
Human, Mouse (Murine)
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Host
Rabbit
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9
Clonality (Clone)
Polyclonal ()
Conjugate
This BID antibody is un-conjugated
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Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Options
Supplier
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Supplier Product No.
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Immunogen This Bid antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 68-103 AA from human Bid.
Clone RB0957-RB0958
Isotype Ig
Specificity This Bid antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 78~108 amino acids from the BH3 domain of human Bid.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name Bid (BID Antibody Abstract)
Background Bid is a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. Bid is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8), CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release.
Synonyms: BH3-interacting domain death agonist, BID, p22 BID
Molecular Weight 21994 DA
Gene ID 637
UniProt P55957
Research Area Apoptosis/Necrosis, Cancer, Cell Structure
Pathways Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
Application Notes WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 1.855 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-BH3 Interacting Domain Death Agonist (BID) (AA 68-103), (BH3 Domain) antibody (ABIN388099) The anti-Bid BH3 domain Pab (ABIN388099) is used in Western blot to detect Bid BH3 in...
Western Blotting (WB) image for anti-BH3 Interacting Domain Death Agonist (BID) (AA 68-103), (BH3 Domain) antibody (ABIN388099) Western blot analysis of anti-hBid-BH3 Pab (ABIN388099) in mouse lung tissue lysates ...
Immunohistochemistry (IHC) image for anti-BH3 Interacting Domain Death Agonist (BID) (AA 68-103), (BH3 Domain) antibody (ABIN388099) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Product cited in: Pedrini, Sau, Guareschi, Bogush, Brown, Naniche, Kia, Trotti, Pasinelli: "ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2." in: Human molecular genetics, Vol. 19, Issue 15, pp. 2974-86, 2010 (PubMed).

Background publications Wang, Ryter, Dai, Tang, Watkins, Yin, Song, Choi: "Necrotic cell death in response to oxidant stress involves the activation of the apoptogenic caspase-8/bid pathway." in: The Journal of biological chemistry, Vol. 278, Issue 31, pp. 29184-91, 2003 (PubMed).

Degli Esposti, Ferry, Masdehors, Boutin, Hickman, Dive: "Post-translational modification of Bid has differential effects on its susceptibility to cleavage by caspase 8 or caspase 3." in: The Journal of biological chemistry, Vol. 278, Issue 18, pp. 15749-57, 2003 (PubMed).

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