Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) (C-Term), (AA 235-263) antibody

Details for Product No. ABIN388106
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Antigen
Synonyms xCaspase-6, mch2, caspase-6, zgc:112960, CASP6, casp6, Mch2, mCASP-6, MCH2
Epitope
C-Term, AA 235-263
(51), (38), (25), (17), (12), (9), (7), (7), (5), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(217), (102), (85), (13), (6), (2), (1)
Host
Rabbit
(209), (27), (4)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(11), (10), (8), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(200), (108), (80), (55), (40), (32), (30), (14), (8), (5), (5), (4), (1), (1), (1)
Pubmed 3 references available
Quantity 400 μL
Options
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Catalog No. ABIN388106
291.50 $
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Immunogen This CASP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-263 AA from the C-terminal region of human CASP6.
Clone RB06896
Isotype Ig
Specificity This CASP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human CASP6.
Predicted Reactivity Cow (Bovine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CASP6
Background CASP6 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This protein could be processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade.
Synonyms: Caspase-6, CASP-6, Apoptotic protease Mch-2, CASP6, MCH2,
Molecular Weight 33310 DA
Gene ID 839
UniProt P55212
Research Area Apoptosis/Necrosis
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.37 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) (C-Term), (AA 235-263) antibody Western blot analysis of anti-CASP6 Antibody (C-term) (ABIN388106) in mouse liver tissue lysates (35 µg/lane). CASP6 (arrow) was detected using the purified polyclonal antibody.
anti-Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) (C-Term), (AA 235-263) antibody (2) Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with CASP6 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Background publications LeBlanc, Liu, Goodyer et al.: "Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease." in: The Journal of biological chemistry, Vol. 274, Issue 33, pp. 23426-36, 1999 (PubMed).

MacLachlan, El-Deiry: "Apoptotic threshold is lowered by p53 transactivation of caspase-6." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 14, pp. 9492-7, 2002 (PubMed).

Sordet, Rébé, Dubrez-Daloz et al.: "Intracellular redistribution of procaspases during TPA-induced differentiation of U937 human leukemic cells." in: Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, Vol. 16, Issue 8, pp. 1569-70, 2002 (PubMed).

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