BMPR2 antibody (N-Term)

Catalog No. ABIN388741

Product Details anti-BMPR2 Antibody

Target: BMPR2 (Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2))

Binding Specificity: AA 28-59, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BMPR2 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This BMPR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-59 amino acids from the N-terminal region of human BMPR2.

Clone: RB01778

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze-thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Expiry Date: 6 months

References for anti-BMPR2 antibody (ABIN388741)

Lynch, Ahsan: "Correlating the Effects of Bone Morphogenic Protein to Secreted Soluble Factors from Fibroblasts and Mesenchymal Stem Cells in Regulating Regenerative Processes In Vitro." in: Tissue engineering. Part A, (2014) (PubMed).

Srikanth, Kim, Das, Kessler: "BMP signaling induces astrocytic differentiation of clinically derived oligodendroglioma propagating cells." in: Molecular cancer research : MCR, Vol. 12, Issue 2, pp. 283-94, (2014) (PubMed).

Li, Cao, Ma, Wang, Zhang, Luo, Chen, Wu, Meng, Zhang, Yuan, Ma, Huang: "Roles of miR-1-1 and miR-181c in ventricular septal defects." in: International journal of cardiology, Vol. 168, Issue 2, pp. 1441-6, (2013) (PubMed).

Zhang, Mu, Zhou, Vrijens, Roussel, Jiang, Yan: "Binding of carbon nanotube to BMP receptor 2 enhances cell differentiation and inhibits apoptosis via regulating bHLH transcription factors." in: Cell death & disease, Vol. 3, pp. e308, (2012) (PubMed).

Jara, Chacón, Burgos, Droguett, Valdivieso, Ortiz, Troncoso, Mezzano: "Expression of gremlin, a bone morphogenetic protein antagonist,is associated with vascular calcification in uraemia." in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Vol. 24, Issue 4, pp. 1121-9, (2009) (PubMed).

Sehgal, Mukhopadhyay, Xu, Patel, Shah: "Dysfunction of Golgi tethers, SNAREs, and SNAPs in monocrotaline-induced pulmonary hypertension." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 292, Issue 6, pp. L1526-42, (2007) (PubMed).

Ramos, Lamé, Segall, Wilson: "The BMP type II receptor is located in lipid rafts, including caveolae, of pulmonary endothelium in vivo and in vitro." in: Vascular pharmacology, Vol. 44, Issue 1, pp. 50-9, (2005) (PubMed).

Target Details for BMPR2

Target: BMPR2 (Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2))

Alternative Name: BMPR2 (BMPR2 Products)

Synonyms: BMPR-II antibody, BMPR3 antibody, BMR2 antibody, BRK-3 antibody, PPH1 antibody, T-ALK antibody, 2610024H22Rik antibody, AL117858 antibody, AW546137 antibody, BB189135 antibody, BMP-2 antibody, BMPR-2 antibody, BMPRII antibody, Gm20272 antibody, Bmpr-II antibody, bmprii antibody, bone morphogenetic protein receptor type 2 antibody, bone morphogenetic protein receptor, type II b (serine/threonine kinase) antibody, bone morphogenetic protein receptor, type II (serine/threonine kinase) antibody, BMPR2 antibody, bmpr2b antibody, Bmpr2 antibody

Background: BMPR2 is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in BMPR2 have been associated with primary pulmonary hypertension.

Molecular Weight: 115201

Gene ID: 659

NCBI Accession: NP_001195

UniProt: Q13873

Pathways: Growth Factor Binding