|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Teratocarcinoma-Derived Growth Factor 1 (TDGF1) (N-Term) antibody
|Synonyms||CR, CRGF, CRIPTO, Cripto-1, CR1, cripto, cb85, tdgf1, wu:fe01d04, zgc:109829, cr1, cr1a, frl1, xcr1, frl-1, TDGF1, tdgf3, cripto-3|
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA
|3 references available|
|Quantity||400 µL (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Alternative name||CRIPTO (TDGF1)|
|Immunogen||This CRIPTO (TDGF1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26~55 amino acids from the N-terminal region of human TDGF1.|
|Description||Other names: Teratocarcinoma-derived growth factor 1, Epidermal growth factor-like cripto protein CR1, Cripto-1 growth factor, CRGF, CRIPTO|
|Characteristics||Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This CRIPTO (TDGF1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26~55 amino acids from the N-terminal region of human TDGF1.|
|Molecular Weight||21168 DA|
Background: TDGF1 is expressed both in ES cells and during the early phases of embryo development, while in adults it is reactivated in a wide range of epithelial cancers. This protein could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. It is preferentially expressed in gastric and colorectal carcinomas compared to their normal counterparts.
|Application Notes||The suggested dilution is: ELISA~~1:1,000 Western blotting~~1:100~500 Immunohistochemistry~~1:50~100|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Apoptosis/Necrosis, Stem Cells, Cancer, Cell Structure|
|Restrictions||For Research Use only|
Yan, Liu, Luo et al.: "Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway." in: Molecular and cellular biology, Vol. 22, Issue 13, pp. 4439-49, 2002 (PubMed).
Gray, Harrison, Vale: "Cripto forms a complex with activin and type II activin receptors and can block activin signaling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 9, pp. 5193-8, 2003 (PubMed).
Parisi, DAndrea, Lago et al.: "Nodal-dependent Cripto signaling promotes cardiomyogenesis and redirects the neural fate of embryonic stem cells." in: The Journal of cell biology, Vol. 163, Issue 2, pp. 303-14, 2003 (PubMed).
|Hosts||Rabbit (20), Mouse (4), Goat (2)|
|Reactivities||Human (25), Mouse (Murine) (6), Rat (Rattus) (3), Cow (Bovine) (1), Dog (Canine) (1)|
|Applications||Western Blotting (WB) (20), ELISA (19), Immunohistochemistry (IHC) (9), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (5), Immunofluorescence (IF) (2)|
|Conjugates||Biotin (2), FITC (2), HRP (2)|
|Epitopes||N-Term (2), Center (1)|