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GADD45A antibody (Growth Arrest and DNA-Damage-Inducible, alpha) (AA 1-30)

Details for Product anti-GADD45A Antibody No. ABIN389281, Supplier: Log in to see
Antigen
  • MGC53491
  • zgc:91795
  • gadd45a
  • GADD45A
  • ddit1
  • gadd45
  • GADD45
  • AA545191
  • Ddit1
  • DDIT1
  • Gadd45
Alternatives
anti-Human GADD45A antibody for Enzyme Immunoassay
Epitope
AA 1-30, N-Term
14
13
10
6
4
2
2
2
1
1
1
Reactivity
Human
76
28
27
Host
Rabbit
64
13
Clonality (Clone)
Polyclonal ()
Conjugate
This GADD45A antibody is un-conjugated
2
2
2
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Western Blotting (WB)
55
19
11
11
5
4
2
1
Supplier
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Immunogen This GADD45A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human GADD45A.
Clone RB16520
Isotype Ig
Specificity This GADD45A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3~32 amino acids from the N-terminal region of human GADD45A.
Predicted Reactivity Cow (Bovine)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name GADD45A (GADD45A Antibody Abstract)
Background GADD45A responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45A gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms.
Synonyms: Growth arrest and DNA-damage-inducible protein GADD45 alpha, DNA-damage-inducible transcript 1, DDIT-1, GADD45A, DDIT1, GADD45
Molecular Weight 18205 DA
Gene ID 1647
UniProt P24522
Research Area Stem Cells, Protein Modifications
Pathways p53 Signaling, Cell Division Cycle
Application Notes WB = 1:1000, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-GADD45A antibody (Growth Arrest and DNA-Damage-Inducible, alpha) (AA 1-30) (ABIN389281) Western blot analysis of anti-GADD45A Antibody (N-term) (ABIN389281) in Y79 cell line...
Western Blotting (WB) image for anti-GADD45A antibody (Growth Arrest and DNA-Damage-Inducible, alpha) (AA 1-30) (ABIN389281) Western blot analysis of GADD45A (arrow) using rabbit polyclonal GADD45A Antibody (N-...
Background publications Li, Morales, Hwang et al.: "DNA mismatch repair-dependent activation of c-Abl/p73alpha/GADD45alpha-mediated apoptosis." in: The Journal of biological chemistry, Vol. 283, Issue 31, pp. 21394-403, 2008 (PubMed).

Al-Romaih, Sadikovic, Yoshimoto et al.: "Decitabine-induced demethylation of 5' CpG island in GADD45A leads to apoptosis in osteosarcoma cells." in: Neoplasia (New York, N.Y.), Vol. 10, Issue 5, pp. 471-80, 2008 (PubMed).

Zhu, Ren, Korchin et al.: "Soft tissue sarcoma cells are highly sensitive to AKT blockade: a role for p53-independent up-regulation of GADD45 alpha." in: Cancer research, Vol. 68, Issue 8, pp. 2895-903, 2008 (PubMed).

Kearsey, Coates, Prescott et al.: "Gadd45 is a nuclear cell cycle regulated protein which interacts with p21Cip1." in: Oncogene, Vol. 11, Issue 9, pp. 1675-83, 1995 (PubMed).