APP antibody (Amyloid beta (A4) Precursor Protein) (pSer730)

Details for Product anti-APP Antibody No. ABIN389515, Supplier: Log in to see
Antigen
  • APP
  • APP-like
  • APPL
  • Abeta
  • BcDNA:GH04413
  • CG7727
  • Dmel\\CG7727
  • EG:65F1.5
  • appl
  • aaa
  • abeta
  • abpp
  • ad1
  • appi
  • ctfgamma
  • cvap
  • pn2
  • AAA
  • ABETA
  • ABPP
  • AD1
  • APPI
  • CTFgamma
  • CVAP
  • PN-II
  • PN2
  • Abpp
  • Adap
  • Ag
  • Cvap
  • E030013M08Rik
  • betaApp
  • app
  • wu:fj34d10
  • wu:fk65e12
  • zgc:85740
  • beta amyloid protein precursor-like
  • amyloid beta (A4) precursor protein
  • amyloid beta (A4) precursor protein a
  • beta amyloid protein precursor
  • Appl
  • APP
  • app
  • App
  • appa
  • LOC100009546
Alternatives
anti-Human APP antibody for Dot Blot
Epitope
pSer730
101
95
67
36
30
24
23
19
16
16
15
15
14
14
12
10
7
7
7
7
6
6
6
5
5
5
5
5
5
5
5
5
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
820
366
351
40
27
21
19
18
15
13
12
10
7
7
4
4
4
3
2
2
1
Host
Rabbit
579
225
45
6
2
Clonality (Clone)
Polyclonal ()
Conjugate
This APP antibody is un-conjugated
47
37
37
14
13
13
13
12
12
12
12
12
12
12
11
8
8
3
3
2
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
574
318
233
149
148
100
47
38
35
18
14
10
9
8
6
3
2
2
1
1
1
1
Options
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Immunogen This APP Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S730 of human APP.
Clone RB6972
Isotype Ig
Specificity This Phospho-APP-S730 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S730 of human APP.
Predicted Reactivity Mouse (Murine),Pig (Porcine),Monkey,Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name APP (APP Antibody Abstract)
Background APP is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).
Synonyms: Amyloid beta A4 protein [Precursor], APP, ABPP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, Protease nexin-II, PN-II, APPI, PreA4, APP, A4, AD1,
Molecular Weight 86943 DA
Gene ID 351
UniProt P05067
Research Area Apoptosis/Necrosis, Signaling, Phospho-specific antibodies, Protein Modifications, Cell Structure, Transcription Factors, Neurology
Pathways Caspase Cascade in Apoptosis, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.33 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-APP antibody (Amyloid beta (A4) Precursor Protein) (pSer730) (ABIN389515) The anti-Phospho-APP-S730 Pab (ABIN389515) is used in Western blot to detect Phospho-...
Background publications Borroni, Colciaghi, Caltagirone, Rozzini, Broglio, Cattabeni, Di Luca, Padovani: "Platelet amyloid precursor protein abnormalities in mild cognitive impairment predict conversion to dementia of Alzheimer type: a 2-year follow-up study." in: Archives of neurology, Vol. 60, Issue 12, pp. 1740-4, 2003 (PubMed).

Lleó, Berezovska, Ramdya, Fukumoto, Raju, Shah, Hyman: "Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression." in: The Journal of biological chemistry, Vol. 278, Issue 48, pp. 47370-5, 2003 (PubMed).

Zhou, Su, Li, Liu, Ryder, Wu, Gonzalez-DeWhitt, Gelfanova, Hale, May, Paul, Ni: "Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho." in: Science (New York, N.Y.), Vol. 302, Issue 5648, pp. 1215-7, 2003 (PubMed).

Murakami, Irie, Morimoto, Ohigashi, Shindo, Nagao, Shimizu, Shirasawa: "Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease." in: The Journal of biological chemistry, Vol. 278, Issue 46, pp. 46179-87, 2003 (PubMed).

Kim, Kim, Lee, Choi, Kim, Huh, Lee, Han, Rha: "Amyloid beta peptide (Abeta42) activates PLC-delta1 promoter through the NF-kappaB binding site." in: Biochemical and biophysical research communications, Vol. 310, Issue 3, pp. 904-9, 2003 (PubMed).