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CDK1 antibody (Cyclin-Dependent Kinase 1) (pSer39)

Details for Product anti-CDK1 Antibody No. ABIN389538, Supplier: Log in to see
Antigen
  • 5363
  • cdc
  • cdc-2
  • cdc2
  • Cdc2
  • CDC2
  • cdc2-a
  • Cdc2a
  • CDC2A
  • CDC2AAT
  • cdc2Dm
  • cdc2x1.1
  • cdc28a
  • CDC28A
  • CDCDm
  • Cdk-1
  • Cdk1
  • CDK1
  • cdk1
  • CDK1/CDC2
  • CDK2
  • CDKA1
  • CDKA;1
  • cell division control 2
  • CG5363
  • CYCLIN-DEPENDENT KINASE A;1
  • Dcdc2
  • dCdk1
  • Dmcdc2
  • Dm cdc2
  • DmCdc2
  • DmCdk1
  • Dmel\\CG5363
  • group 4
  • l(2)31Eh
  • p34
  • p34cdc2
  • P34CDC2
  • POL3
  • pold
  • PSTAIR
  • wu:fc30e01
  • xcdc2
  • zgc:92032
Alternatives
anti-Human CDK1 antibody for Immunocytochemistry
Epitope
pSer39
96
69
45
33
32
27
20
19
18
15
14
14
14
14
14
8
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5
5
5
4
4
4
4
3
3
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
608
255
226
28
25
23
17
10
9
5
5
5
4
4
2
2
1
1
1
1
1
1
1
1
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1
Host
Rabbit
496
151
Clonality (Clone)
Polyclonal ()
Conjugate
This CDK1 antibody is un-conjugated
27
24
21
17
16
16
5
5
5
5
5
5
5
5
5
1
1
Application
Dot Blot (DB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
519
242
162
97
92
73
56
38
33
14
10
9
7
6
6
2
1
1
1
Supplier
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Immunogen This CDK1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S39 of human CDK1.
Clone RB7849
Isotype Ig
Specificity This Phospho-CDK1-S39 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S39 of human CDK1.
Predicted Reactivity Cow (Bovine),Chicken,Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CDK1 (CDK1 Antibody Abstract)
Background The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control.
Synonyms: V-abl Abelson murine leukemia viral oncogene homolog 1, ABL1,
Molecular Weight 34095 DA
Gene ID 983
UniProt P06493
Research Area Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Cell Structure
Pathways Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes DB = 1:500, WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.41 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Dot Blot (DB) image for anti-CDK1 antibody (Cyclin-Dependent Kinase 1) (pSer39) (ABIN389538) Dot blot analysis of anti-CDK11-S39 Phospho-specific Pab (ABIN389538) on nitrocellulo...
Western Blotting (WB) image for anti-CDK1 antibody (Cyclin-Dependent Kinase 1) (pSer39) (ABIN389538) The anti-Phospho-CDK1-S39 Pab (ABIN389538) is used in Western blot for detection in R...
Immunohistochemistry (IHC) image for anti-CDK1 antibody (Cyclin-Dependent Kinase 1) (pSer39) (ABIN389538) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Background publications Krämer, Mailand, Lukas, Syljuåsen, Wilkinson, Nigg, Bartek, Lukas: "Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase." in: Nature cell biology, Vol. 6, Issue 9, pp. 884-91, 2004

Shapira, Ben-Izhak, Bishara, Futerman, Minkov, Krausz, Pagano, Hershko: "Alterations in the expression of the cell cycle regulatory protein cyclin kinase subunit 1 in colorectal carcinoma." in: Cancer, Vol. 100, Issue 8, pp. 1615-21, 2004

Chow, Siu, Ho, Ma, Ho, Poon: "Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints." in: The Journal of biological chemistry, Vol. 278, Issue 42, pp. 40815-28, 2003