WISP3 antibody (AA 305-335)

Catalog No. ABIN390189

This anti-WISP3 antibody is a Rabbit Polyclonal antibody detecting WISP3 in WB and IHC (p). Suitable for Human. This Primary Antibody has been cited in 1 publication.

Quick Overview for WISP3 antibody (AA 305-335) (ABIN390189)

Target: WISP3 (Wnt1 Inducible Signaling Pathway Protein 3 (WISP3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WISP3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB2145-2146

Product Details anti-WISP3 Antibody

Binding Specificity: AA 305-335

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This WISP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 305-335 amino acids from the Central region of human WISP3.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-WISP3 antibody (ABIN390189)

Ji, Jia, Jia, Ji, Hargest, Jiang: "WISP-2 in human gastric cancer and its potential metastatic suppressor role in gastric cancer cells mediated by JNK and PLC-? pathways." in: British journal of cancer, Vol. 113, Issue 6, pp. 921-33, (2015) (PubMed).

Target Details for WISP3

Target: WISP3 (Wnt1 Inducible Signaling Pathway Protein 3 (WISP3))

Alternative Name: WISP3

Background: WISP3 is a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. WISP3 is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of the WISP3 gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis.

Molecular Weight: 39293

Gene ID: 8838

NCBI Accession: NP_003871, NP_937882

UniProt: O95389

Pathways: WNT Signaling, Growth Factor Binding